Dépôt numérique

History of allergic diseases and risk of cancer

Rousseau, Marie-Claude ORCID logoORCID: https://orcid.org/0000-0001-5215-8086; Parent, Marie-Élise ORCID logoORCID: https://orcid.org/0000-0002-4196-3773; Désy, Marie et Siemiatycki, Jack (2007). History of allergic diseases and risk of cancer In: 40th Annual Meeting of the Society for Epidemiologic Research June 19–22, 2007, June 19-22, 2007, Boston, MA.

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Epidemiological studies focusing on allergic diseases in relation to cancer risk have generated inconsistent results, suggesting beneficial, harmful, or no effects. We studied whether a history of asthma and eczema was associated with the risk of 7 cancer types among men. In the 1980s, we conducted a large population-based case-control study of environmental causes of cancer among males in Montreal, Canada, including several types of cancer. Information collected by interview included prior diagnosis of asthma, eczema and other medical conditions, age at diagnosis, and medication use. We compared the self-reported medical history from cases of stomach (n = 227), colon (n = 438), rectal (n = 236), lung (n = 755), prostate (n = 397), bladder (n = 438) cancer and non-Hodgkin’s lymphoma (n = 197), to that of population controls (N ¼ 512). Logistic regression models were used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CI) for the associations between asthma and eczema, and each cancer type. Among population controls, the prevalences of asthma and eczema were 5.3% and 4.5%. Prior history of asthma was associated with none of the cancers, but when restricting exposure to those who used medication, asthma was negatively associated with stomach cancer: OR = 0.27 [95% CI: 0.1–0.9]. Prior history of eczema was inversely associated with all cancers, but only lung cancer achieved statistical significance: OR = 0.34 [95% CI: 0.2–0.7]. It has been hypothesized that allergic conditions, resulting from a hyper-reactive immune system, might lead to a more efficient elimination of abnormal cells and thus lower cancer risks. Although limited by small numbers, our results bring some support to this hypothesis.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: Afiche scientifique no 400 American journal of Epidemiology (2007) 165(11):S100
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 29 mars 2024 20:18
Dernière modification: 29 mars 2024 20:18
URI: https://espace.inrs.ca/id/eprint/14319

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