Rousseau, Marie-Claude 
ORCID: https://orcid.org/0000-0001-5215-8086; Conus, Florence; Parent, Marie-Élise ORCID: https://orcid.org/0000-0002-4196-3773 et Siemiatycki, Jack
(2010).
History of Allergic Diseases and Risk of Lung Cancer
In: 43rd Annual Meeting society for Epidemiologic Research, June 23-26, 2010, Anaheim, California.
Résumé
The epidemiological evidence on history of allergic diseases in relation to
lung cancer is generally inconsistent, suggesting beneficial, harmful, or no
effects. We studied whether a history of eczema, asthma or hay fever was
associated with the risk of lung cancer in a population-based case-control
study conducted in the Montreal metropolitan area, Canada (1996-2002).
Controls were selected from the electoral list and frequency-matched to
cases on sex, age, and area of residence. Interviews were conducted with
1196 incident lung cancer cases and 1508 controls to elicit information on
prior diagnosis of eczema, asthma and hay fever, age at diagnosis and
medication use, as well as occupational, lifestyle and detailed lifetime
smoking history. Separate logistic regression models were used to estimate
odds ratios (ORs) and 95% confidence intervals (CI) for the associations
between eczema, asthma and hay fever, and lung cancer adjusting for
smoking and other confounders. The prevalence of eczema, asthma and
hay fever was 6%, 10%, and 9% among population controls, and 5%,
11%, and 3% among cases, respectively. No associations were observed
between a history of eczema or asthma and lung cancer. However, a reported
history of hay fever was negatively associated with lung cancer (OR = 0.40,
95%CI = 0.3-0.6); this persisted when hay fever was defined by both
physician diagnosis and medication use (OR = 0.36, 95%CI = 0.2-0.6).
Although it is unclear whether the association between hay fever and lung
cancer truly reflects hypothesized immunological mechanisms (enhanced
immune surveillance, control of inflammatory response through hay fever
medication), our results are consistent with those from previous studies.
| Type de document: | Document issu d'une conférence ou d'un atelier |
|---|---|
| Informations complémentaires: | Meeting Abstract 260 American Journal of Epidemiology (2010) 171(Suppl. 11):S65 |
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 01 avr. 2024 02:57 |
| Dernière modification: | 01 avr. 2024 02:57 |
| URI: | https://espace.inrs.ca/id/eprint/14317 |
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