Dépôt numérique

History of Allergic Diseases and Risk of Lung Cancer

Rousseau, Marie-Claude ORCID logoORCID: https://orcid.org/0000-0001-5215-8086; Conus, Florence; Parent, Marie-Élise ORCID logoORCID: https://orcid.org/0000-0002-4196-3773 et Siemiatycki, Jack (2010). History of Allergic Diseases and Risk of Lung Cancer In: 43rd Annual Meeting society for Epidemiologic Research, June 23-26, 2010, Anaheim, California.

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The epidemiological evidence on history of allergic diseases in relation to lung cancer is generally inconsistent, suggesting beneficial, harmful, or no effects. We studied whether a history of eczema, asthma or hay fever was associated with the risk of lung cancer in a population-based case-control study conducted in the Montreal metropolitan area, Canada (1996-2002). Controls were selected from the electoral list and frequency-matched to cases on sex, age, and area of residence. Interviews were conducted with 1196 incident lung cancer cases and 1508 controls to elicit information on prior diagnosis of eczema, asthma and hay fever, age at diagnosis and medication use, as well as occupational, lifestyle and detailed lifetime smoking history. Separate logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI) for the associations between eczema, asthma and hay fever, and lung cancer adjusting for smoking and other confounders. The prevalence of eczema, asthma and hay fever was 6%, 10%, and 9% among population controls, and 5%, 11%, and 3% among cases, respectively. No associations were observed between a history of eczema or asthma and lung cancer. However, a reported history of hay fever was negatively associated with lung cancer (OR = 0.40, 95%CI = 0.3-0.6); this persisted when hay fever was defined by both physician diagnosis and medication use (OR = 0.36, 95%CI = 0.2-0.6). Although it is unclear whether the association between hay fever and lung cancer truly reflects hypothesized immunological mechanisms (enhanced immune surveillance, control of inflammatory response through hay fever medication), our results are consistent with those from previous studies.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: Meeting Abstract 260 American Journal of Epidemiology (2010) 171(Suppl. 11):S65
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 01 avr. 2024 02:57
Dernière modification: 01 avr. 2024 02:57
URI: https://espace.inrs.ca/id/eprint/14317

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