Pintos, Javier; Parent, Marie-Élise 
ORCID: https://orcid.org/0000-0002-4196-3773; Rousseau, Marie-Claude ORCID: https://orcid.org/0000-0001-5215-8086 et Siemiatycki, Jack
(2007).
Occupational exposure to asbestos and manmade vitreous fibers, and risk of lung cancer: Evidence from two case-control studies in Montreal, Canada
In: 40th Annual Meeting of the Society for Epidemiologic Research, June 19–22, 2007, Boston, MA.
Résumé
Objective: to investigate the association between occupational exposure to
asbestos and man-made vitreous fibers (MMVF) and risk of lung cancer
among males. Methods: Data were collected in two population-based casecontrol studies conducted in Montreal (Study I: 1979–1986, and Study II:
1996–2001). Study I included 857 lung cancer cases and 1066 population
and cancer controls, and Study II 858 cases and 1295 population controls.
Interviews elicited a detailed job history; lifetime exposure to 294 substances, including asbestos, glass fibers, and mineral wool fibers, was assessed
by a team of chemists/hygienists. Due to their low prevalence of exposure,
glass fibers and mineral wool fibers were analyzed together as MMVF.
Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated adjusting for age, SES, respondent status, ethnicity, and smoking history.
Results: In Study I, substantial exposure to asbestos alone was associated
with a marginally significant increase in risk (OR ¼ 2.23; 95% CI:0.9–5.4),
but no excess risks were noted for MMVF alone or for asbestos and MMVF
together. In Study II we did not find increased risks of lung cancer associated with asbestos alone or MMVF alone, whereas the OR associated with
both exposures together at the substantial level was 2.20 (95% CI: 0.8–6.3).
Discussion: Occupational exposure to asbestos was associated with lung
cancer for those cases diagnosed in the early 1980s, but not those in the late
1990s, plausibly reflecting a reduction in levels of exposure in the workplace in Quebec. High levels of exposure to MMVF could also be associated with lung cancer.
| Type de document: | Document issu d'une conférence ou d'un atelier |
|---|---|
| Informations complémentaires: | Affiche scientifique 406 American Journal of Epidemiology 165(11: Suppl. 1):S102 |
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 12 mars 2024 16:01 |
| Dernière modification: | 12 mars 2024 16:01 |
| URI: | https://espace.inrs.ca/id/eprint/14312 |
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