Dépôt numérique

Is there a link between stress at work and cancer risk

Parent, Marie-Élise ORCID logoORCID: https://orcid.org/0000-0002-4196-3773; Rousseau, Marie-Claude ORCID logoORCID: https://orcid.org/0000-0001-5215-8086; Pintos, Javier; Nicolau, Belinda; Désy, Marie et Siemiatycki, Jack (2007). Is there a link between stress at work and cancer risk In: 40th Annual Meeting Society for Epidemiologic Research, June 19-22, 2007, Boston, Massachusetts,.

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One may postulate that stress modulates cancer risk either indirectly, through changes in lifestyle factors, or directly, by altering endocrinologic, immune functions or DNA repair capacity. We present here results from an analysis of a case-control study undertaken among Montreal men to investigate the association between occupational, lifestyle factors, and several cancer types, this time focusing on the role of stress at work. Interviews were carried out with incident cases of lung (n = 761), colon (n = 439), bladder (n = 439), prostate (n = 400), stomach (n = 228), kidney (n = 158), pancreatic (n = 94), rectal (n = 236), esophageal (n = 91) cancers, melanoma (n = 94), non-Hodgkin’s lymphoma (n = 197), and 533 population controls. Work histories included probing, for each job held, whether it was stressful most of the time, and why. Logistic regression analyses assessed the odds ratio (OR) and 95% confidence interval (95% CI) for stress at work in relation to each cancer type, adjusting for site-specific potential confounders. Using men having held no stressful jobs as a reference, the OR for men who reported having held stressful jobs for over 30 years was 1.8 (95% CI = 0.9–3.4) for esophageal, 1.5 (95% CI = 0.9–2.4) for stomach, 1.5 (95% CI = 1.0–2.2) for lung, 1.4 (95% CI = 0.9–2.0) for prostate, 1.7 (95% CI = 1.2–2.5) for colon, 1.5 (95% CI = 0.9–2.4) for rectal cancers, and 1.7 (95% CI = 1.0–2.8) for non-Hodgkin’s lymphoma. Duration-response trends were apparent for colon and lung cancers, and non-Hodgkin’s lymphoma. No clear associations emerged for cancers of the bladder, pancreas, kidney, and melanoma. These findings, providing some support for a link between stress at work and risk of cancer at various sites, need to be replicated in other studies.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: Meeting Abstract 012 American JOurnal of Epidemiology (2007) 165(Suppl. 11):S3
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 01 avr. 2024 18:49
Dernière modification: 01 avr. 2024 18:49
URI: https://espace.inrs.ca/id/eprint/14302

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