Dépôt numérique

Childhood socioeconomic position in relation to cancer: Evidence from a Canadian population based case-control study

Nicolau, Belinda; Parent, Marie-Élise ORCID logoORCID: https://orcid.org/0000-0002-4196-3773; Rousseau, Marie-Claude ORCID logoORCID: https://orcid.org/0000-0001-5215-8086; Désy, Marie et Siemiatycki, Jack (2007). Childhood socioeconomic position in relation to cancer: Evidence from a Canadian population based case-control study In: 40th Annual Meeting Society for Epidemiologic Research, June 19-22, 2007, Boston, Massachusetts,.

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Several lines of evidence suggest that socioeconomic position (SEP) in childhood is associated with adult health. Yet most studies to date have focused on mortality and data on morbidity outcomes are needed. In this study, we examined the association between SEP in childhood (measured by self-reported financial hardship in childhood) and cancer at several sites. We used data from a population-based case-control study which was undertaken in Montreal in the 1980s. Interviews were carried out on 3730 incident cancer cases and 533 population controls. We estimated the relative risk for each cancer site in relation to SEP in childhood. Following adjustment for covariates which included SEP in adulthood, subjects who grew up in a favorable SEP had reduced risks of cancer of the stomach (odds ratio [OR] = 0.64, 95% confidence intervals [95% CI] = 0.4–0.9), rectum (OR = 0.62, 95% CI = 0.4–0.9), lung (OR = 0.72, 95% CI = 0.5– 1.0), prostate (OR = 0.52, 95% CI = 0.3–0.7), bladder (OR = 0.72, 95% CI = 0.5–1.0) and kidney (OR = 0.63 95% CI = 0.4–0.9). The inclusion of current SEP in the models substantially attenuated the effect of childhood SEP in some cancer sites (e.g., lung), while in other sites the effects of SEP remained the same (e.g., stomach, prostate, kidney). Childhood SEP was not associated with melanoma, lymphoma, colon, pancreas, or liver cancer. However, growing up in a favorable financial situation reduced the risk of several cancers independently of SEP in adulthood. These results are in agreement with the evidence that low childhood SEP increases the risk of chronic diseases in adulthood. 307 SOCIOECONOMIC CHARACTERISTICS AND LUNG FUNCTION. THE MESA LUNG STUDY. *G S Lovasi, A Diez Roux, E A Hoffman, L J Smith, R Jiang, J J Carr, R G Barr (Columbia University, New York, NY, 10027) The Multi-Ethnic Study of Atherosclerosis (MESA) study provides an opportunity to quantify health disparities in lung function and lung disease across several measures of socioeconomic position, including household income, education, employment status, and wealth. The MESA-Lung Study assessed spirometry following ATS/ERS standards among 3,800 MESA participants. All models were adjusted for age, sex, height, race/ethnicity, and study site. We considered further adjustment for tobacco exposure, body mass index, immigrant status, occupational exposures, and history of respiratory illness. To date, spirometry data was available for 3,366 participants, with a mean age of 65 years. Compared to a household income above $50,000/yr, an income below $25,000/yr was associated a 141 ml (95% CI: 95 to 187) lower forced expiratory volume in one second (FEV1), a 150 ml (95% CI: 97 to 204) lower forced vital capacity (FVC), and an odds ratio for chronic obstructive pulmonary disease (COPD) of 1.6 (95% CI: 1.1 to 2.3). Adjustment for other covariates did not eliminate the statistical significance of these associations. Associations with FEV1 and FEV persisted among retired participants and those who had never smoked (p 0.01). Education, employment status, and wealth were associated with FEV1 and FVC, and income was associated FEV1/FVC ratio, but these associations became non-significant in fully adjusted models. For models with income, the addition of education, employment status and wealth explained less than one percent of the variation. In conclusion, higher income was associated with better lung function in this multiethnic cohort, but education, employment status and wealth did not offer further explanatory power.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: Meeting Abstract 306 American Journal of Epidemiology(2007) 165(Suppl. 11):S77
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 01 avr. 2024 18:40
Dernière modification: 01 avr. 2024 18:51
URI: https://espace.inrs.ca/id/eprint/14300

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