Dépôt numérique

In vitro and in vivo roles of CD132 (γc)-dependent cytokines in neutrophils and inflammation

Girard, Denis ORCID logoORCID: https://orcid.org/0000-0002-3342-5027 et Pelletier, Martin (2007). In vitro and in vivo roles of CD132 (γc)-dependent cytokines in neutrophils and inflammation In: Phenotypic and functional changes of neutrophils activated by recently identified modulators. Research Signpost, Trivandrum, Kerala, India, pp. 27-50.

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A review. Different cytokines are known to utilize a common receptor subunit. Interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-21 share the common cytokine receptor γ chain (CD132) and are referred to as the CD132-dependent cytokines. This family of cytokines is essential for the development, activation and homeostasis of B, T and NK cells. A single mutation in the CD132 encoding gene results in a severe primary deficiency known as X-linked severe combined immunodeficiency (X-SCID). The recent discovery that polymorphonuclear neutrophil cells express the CD132 subunit at their surface sheds new light on the role of CD132-dependent cytokines in inflammatory diseases. Here, we review the effects of these cytokines on polymorphonuclear neutrophil cell physiol. in vitro and in vivo, as well as the contribution of these cytokines to inflammatory responses. We will briefly introduce the CD132-dependent cytokines and their receptors, followed by the general biol. of these cytokines.

Type de document: Chapitre de livre
Mots-clés libres: B cell; Cell activation; Inflammation; Mutation; Neutrophil; T cell; Interleukin 15; Interleukin 2; Interleukin 21; Interleukin 4; Interleukin 7; Interleukin 9; Lymphocyte; Immunodeficiency
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 04 mars 2024 03:17
Dernière modification: 04 mars 2024 03:17
URI: https://espace.inrs.ca/id/eprint/14236

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