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Cytoskeleton breakdown in spontaneous and anti-cancer drug-induced neutrophil apoptosis

Girard, Denis ORCID logoORCID: https://orcid.org/0000-0002-3342-5027 (2007). Cytoskeleton breakdown in spontaneous and anti-cancer drug-induced neutrophil apoptosis In: Phenotypic and functional changes of neutrophils activated by recently identified modulators. Research Signpost, Trivandrum, Kerala, India, pp. 121-134.

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A review. Numerous agents are known to modulate neutrophil apoptosis. Among these, several are pro-apoptotic mols. whose actions yield different characteristics of apoptotic cells, including loss of cell surface mols., condensation of heterochromatin and degrdn. of DNA, apparition of pyknotic nucleus, and cell shrinkage. During the past few years, my lab. has investigated another aspect characteristic of apoptotic cells: the breakdown of the cytoskeleton as evidenced by the degrdn. of cytoskeletal proteins during spontaneous or anti-cancer agent-induced human neutrophil apoptosis. In this chapter, I will summarize the results and observations made in this area of research, esp. in neutrophils treated with two anticancer agents, Viscum album agglutinin-I and arsenic trioxide. In addn., I will include recent observations obtained with some granulocyte cell lines as well as with circulating human eosinophils. [on SciFinder(R)]

Type de document: Chapitre de livre
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 12 mars 2024 17:10
Dernière modification: 12 mars 2024 17:10
URI: https://espace.inrs.ca/id/eprint/14235

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