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A distinctive role for galectin-7 in cancer?


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St-Pierre, Yves ORCID logoORCID: https://orcid.org/0000-0002-1948-2041; Campion, Carole G. et Grosset, Andree-Anne (2012). A distinctive role for galectin-7 in cancer? Frontiers in Bioscience , vol. 17 , nº 2. pp. 438-450. DOI: 10.2741/3937.

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The galectins are a family of evolutionay-conserved carbohydrate-binding proteins. They are distributed widely in all living organisms and have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis. Several members of the galectin family have also been shown to be involved in cancer progression and metastasis. In the case of galectin-7, several studies have reported alterations in its expression pattern during cancer progression. In a variety of tumors, its expression can range from being completely down-regulated to highly up-regulated. Accordingly, its precise role in this field is still debated. The evidence shows tiiat galectin-7 may promote or inhibit cancer development. In this article, we review the data concerning expression and roles of galectin-7 in cancer and propose a comprehensive view of its contribution during cancer progression.

Type de document: Article
Mots-clés libres: Galectins; Apoptosis; Mammary Cancer; Mammary Myoepithelial Cells; p53
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 08 mars 2024 20:22
Dernière modification: 08 mars 2024 20:22
URI: https://espace.inrs.ca/id/eprint/14094

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