Leishmania promastigotes: building a safe niche within macrophages

Moradin, Neda et Descoteaux, Albert ORCID: https://orcid.org/0000-0002-0633-5309 (2012). Leishmania promastigotes: building a safe niche within macrophages Frontiers in Cellular and Infection Microbiology , vol. 2 , nº 121. pp. 1-7. DOI: 10.3389/fcimb.2012.00121.

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Résumé

Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accumulation of F-actin and disruption of phagosomal lipid microdomains. Functionally, this LPG-mediated inhibition of phagosome maturation is characterized by an impaired assembly of the NADPH oxidase and the exclusion of the vesicular proton-ATPase from phagosomes. In this chapter, we review the current knowledge concerning the nature of the intra-macrophage compartment in which Leishmania donovani promastigotes establish infection. We also describe how LPG enables this parasite to remodel the parasitophorous vacuole.

Type de document:	Article
Mots-clés libres:	Leishmania; lipophosphoglycan; macrophage; phagosome; virulence.
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	04 mars 2024 16:31
Dernière modification:	04 mars 2024 16:31
URI:	https://espace.inrs.ca/id/eprint/14064

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