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Niveljalkaisten välityksellä leviävät virukset hyödyntävät isännän immuunipuolustusta infektion aikaansaamiseksi (How arthropod-borne viruses exploit dendritic cells to invade our body)

Lozach, Pierre-Yves et Helenius, Ari (2012). Niveljalkaisten välityksellä leviävät virukset hyödyntävät isännän immuunipuolustusta infektion aikaansaamiseksi (How arthropod-borne viruses exploit dendritic cells to invade our body) Duodecim; Lääketieteellinen Aikakauskirja , vol. 128 , nº 18. pp. 1929-35.

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Résumé


In Ralf Pettersson, we have lost an influential and internationally recognized investigator with a significant impact in the field of animal virology. The Bunyaviridae constitute the viral family that he studied the most. These are relatively simple enveloped viruses with a tri-segmented negative-sense single-stranded RNA genome. With few exceptions, bunyaviruses are transmitted by arthropod vectors and are introduced into the skin of hosts via bites of infected arthropods. Dermal dendritic cells (DCs) are among the first cells to encounter incoming viruses. In this short review, we will discuss how arthropod-borne viruses exploit DCs to spread throughout the body of the human host. The mechanism depends on interactions with DC-SIGN, a C-type lectin abundantly expressed on DCs.

Type de document: Article
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 08 mars 2024 19:51
Dernière modification: 08 mars 2024 19:51
URI: https://espace.inrs.ca/id/eprint/14056

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