Dépôt numérique

The ubiquitous hammerhead ribozyme

Hammann, Christian; Luptak, Andrej; Perreault, Jonathan ORCID logoORCID: https://orcid.org/0000-0003-4726-6319 et De La Peña, Marcos (2012). The ubiquitous hammerhead ribozyme RNA , vol. 18 , nº 5. pp. 871-885. DOI: 10.1261/rna.031401.111.

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The hammerhead ribozyme is a small catalytic RNA motif capable of endonucleolytic (self-) cleavage. It is composed of a catalytic core of conserved nucleotides flanked by three helices, two of which form essential tertiary interactions for fast self-scission under physiological conditions. Originally discovered in subviral plant pathogens, its presence in several eukaryotic genomes has been reported since. More recently, this catalytic RNA motif has been shown to reside in a large number of genomes. We review the different approaches in discovering these new hammerhead ribozyme sequences and discuss possible biological functions of the genomic motifs.

Type de document: Article
Mots-clés libres: Catalytic RNA; Database searches; Homology; Retrotransposons; Structure
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 07 mars 2024 20:23
Dernière modification: 07 mars 2024 20:23
URI: https://espace.inrs.ca/id/eprint/14035

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