Membrane fusion-mediated autophagy induction enhances morbillivirus cell-to-cell spread

Delpeut, Sebastien; Rudd, Penny A.; Labonté, Patrick ORCID: https://orcid.org/0000-0001-7262-3125 et von Messling, Véronica (2012). Membrane fusion-mediated autophagy induction enhances morbillivirus cell-to-cell spread Journal of Virology , vol. 86 , nº 16. pp. 8527-8535. DOI: 10.1128/JVI.00807-12.

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Résumé

In the context of viral infections, autophagy induction can be beneficial or inhibitory. Within the Paramyxoviridae family, only morbilliviruses have been investigated and are reported to induce autophagy. Here we show that morbilliviruses rapidly induce autophagy and require this induction for efficient cell-to-cell spread. Coexpression of both glycoproteins in cells expressing one of the cellular receptors was required for autophagy induction, and LC3 punctum formation, indicative of autophagy, was mainly obsd. in syncytia. A similar correlation between syncytium formation and autophagy induction was also obsd. for other paramyxovirus glycoproteins, suggesting that membrane fusion-mediated autophagy may be common among paramyxoviruses and possibly other enveloped viruses.

Type de document:	Article
Mots-clés libres:	-
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	07 mars 2024 16:25
Dernière modification:	07 mars 2024 16:25
URI:	https://espace.inrs.ca/id/eprint/14012

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