Delpeut, Sébastien; Rouxel, Ronan Nicolas et von Messling, Véronika (2012). L'étude de la maladie de Carré chez ses hôtes naturels : un modèle de pathogenèse morbillivirale Virologie , vol. 16 , nº 3. pp. 158-167. DOI: 10.1684/vir.2012.0450.
Ce document n'est pas hébergé sur EspaceINRS.Résumé
Morbilliviruses cause a severe and sometimes lethal disease in their respective hosts, which is characterized by a generalized immunosuppression, respiratory and gastro-intestinal clinical signs, and occasional neurological complications. This similarity in the biology of different members of the morbillivirus genus constitutes the basis for the study of canine distemper virus in its natural hosts as a model for the characterization of morbillivirus pathogenesis. In combination with the reverse genetics technology, which allows the production of recombinant viruses carrying specific genetic modifications, this model has made important contributions to our understanding of the mechanisms underlying morbillivirus immunosuppression, dissemination, and neuroinvasion.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | morbillivirus; virus de la maladie de carré; pathogenèse; suppression immunitaire; complications neurologiques |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 07 mars 2024 16:21 |
| Dernière modification: | 07 mars 2024 16:21 |
| URI: | https://espace.inrs.ca/id/eprint/14011 |
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