Besin, Gilles; Yousefi, Mitra; Saba, Ingrid; Klinck, Roscoe; Pandolfi, Pier Paolo et Duplay, Pascale (2012). Dok-1 overexpression promotes development of gammadelta natural killer T cells European Journal of Immunology , vol. 42 , nº 9. pp. 2491-504. DOI: 10.1002/eji.201242421.
Ce document n'est pas hébergé sur EspaceINRS.Résumé
In T cells, two members of the Dok family, Dok-1 and Dok-2, are predominantly expressed. Recent evidence suggests that they play a negative role in T-cell signaling. In order to define whether Dok proteins regulate T-cell development, we have generated transgenic mice overexpressing Dok-1 in thymocytes and peripheral T cells. We show that overexpression of Dok-1 retards the transition from the CD4(-) CD8(-) to CD4(+) CD8(+) stage. Moreover, there is a specific expansion of PLZF-expressing Vgamma1.1(+) Vdelta6.3(+) T cells. This subset of gammadelta T cells acquires innate characteristics including rapid IL-4 production following stimulation and requiring SLAM-associated adaptor protein (SAP) for their development. Moreover, Dok-1 overexpression promotes the generation of an innate-like CD8(+) T-cell population that expresses Eomesodermin. Altogether, these findings identify a novel role for Dok-1 in the regulation of thymic differentiation and in particular, in the development of PLZF(+) gammadelta T cells.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | γδ T cell; Dok; PLZF; SAP; Thymocyte development |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 06 mars 2024 15:15 |
| Dernière modification: | 06 mars 2024 15:15 |
| URI: | https://espace.inrs.ca/id/eprint/13989 |
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