Bankoti, Rashmi; Gupta, Kshitiz; Levchenko, Andre et Stäger, Simona 
ORCID: https://orcid.org/0000-0001-5508-9565
(2012).
Marginal Zone B Cells Regulate Antigen-Specific T Cell Responses during Infection
Journal of Immunology
, vol. 188
, nº 8.
pp. 3961-3971.
DOI: 10.4049/jimmunol.1102880.
Résumé
Marginal zone B cells (MZB) participate in the early immune response to several pathogens. In this study, we show that in mu MT mice infected with Leishmania donovani, CD8 T cells displayed a greater cytotoxic potential and generated more effector memory cells compared with infected wild type mice. The frequency of parasite-specific, IFN-gamma(+) CD4 T cells was also increased in mu MT mice. B cells were able to capture parasites, which was associated with upregulation of surface IgM and MyD88-dependent IL-10 production. Moreover, MZB presented parasite Ags to CD4 T cells in vitro. Depletion of MZB also enhanced T cell responses and led to a decrease in the parasite burden but did not alter the generation of effector memory T cells. Thus, MZB appear to suppress protective T cell responses during the early stages of L. donovani infection.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | - |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 06 mars 2024 15:02 |
| Dernière modification: | 06 mars 2024 15:02 |
| URI: | https://espace.inrs.ca/id/eprint/13981 |
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