Vanharen, Marion; Mahbeer, Thomas; Léveillé, Alexanne; Méthot, Audrey; Samountry, Phonsiri et Girard, Denis 
ORCID: https://orcid.org/0000-0002-3342-5027
(2023).
Impact of gold nanoparticles (AuNPs) in human neutrophils in vitro and in leukocytes attraction in vivo: A sex-based analysis
Environmental Toxicology and Pharmacology
, vol. 104
, nº 104319.
pp. 1-10.
DOI: 10.1016/j.etap.2023.104319.
Résumé
Some differences exist between the male and female immune systems. Despite this, a sex-based analysis is not frequently performed in most studies. Knowing that inflammation is a common undesired effect observed resulting from nanoparticle (NP) exposure, we investigate here how gold NPs with a primary size of 20 (AuNP(20)) and 70 nm (AuNP(70)) will alter the biology of polymorphonuclear neutrophil cells (PMNs) isolated from men and women as well as their potential pro-inflammatory effect in vivo in male and female mice. We found that AuNP(20) significantly delay apoptosis only in PMN isolated from men. The production of interleukin (IL)- 8 by PMNs was increased by both AuNPs regardless of sex although significance was only observed in AuNP(20)-induced PMNs. Using the murine air pouch model of inflammation, AuNPs did not induce a neutrophilic infiltration regardless of sex. In conclusion, AuNPs could differently alter the biology of PMNs according to sex.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Air pouch; Apoptosis; Cytokines; Gender; Nanoparticles; Neutrophils |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 04 janv. 2024 14:47 |
| Dernière modification: | 04 janv. 2024 14:47 |
| URI: | https://espace.inrs.ca/id/eprint/13952 |
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