Dépôt numérique

Using Proteins As Markers for Anabolic Steroid Abuse: A New Perspective in Doping Control?

Sansoucy, Maxime et Naud, Jean-François ORCID logoORCID: https://orcid.org/0000-0001-8667-111X (2023). Using Proteins As Markers for Anabolic Steroid Abuse: A New Perspective in Doping Control? Chemical Research in Toxicology , vol. 36 , nº 8. 1168–1173. DOI: 10.1021/acs.chemrestox.3c00166.

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Drug toxicity is a major concern and has motivated numerousstudiesto elucidate specific adverse mechanisms, with acetaminophen beingthe favorite candidate in toxicology studies. Conversely, androgenicanabolic steroids (AASs) also represent a severe public health issuein sports for elite and non-elite athletes. Supraphysiological dosagesof AASs are associated with various adverse effects, from cardiovascularto neurological repercussions including liver dysfunction. Yet, fewstudies have addressed the toxicity of anabolic steroids, and a significantamount of work will be needed to elucidate and understand steroidtoxicity properly. This Perspective suggests ideas on how proteomicsand liquid chromatography coupled with high-resolution tandem massspectrometry (LC-HRMS/MS) can contribute to (1) pinpoint serum proteinsaffected by substantial doses of anabolic steroids that would representinteresting novel candidates for routine testing and (2) provide additionalknowledge on androgenic anabolic steroid toxicity to help raise awarenesson the harmful effects.

Type de document: Article
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 30 déc. 2023 21:47
Dernière modification: 30 déc. 2023 21:47
URI: https://espace.inrs.ca/id/eprint/13671

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