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Neighbourhood social deprivation and risk of prostate cancer


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Salmon, Charlotte; Quesnel-Vallée, Amélie; Barnett, Tracie A; Benedetti, Andrea; Cloutier, Marie-Soleil ORCID logoORCID: https://orcid.org/0000-0002-8533-4784; Datta, Geetanjali D; Kestens, Yan; Nicolau, Belinda et Parent, Marie-Élise ORCID logoORCID: https://orcid.org/0000-0002-4196-3773 (2023). Neighbourhood social deprivation and risk of prostate cancer British Journal of Cancer , vol. 129 , nº 2. pp. 335-345. DOI: 10.1038/s41416-023-02299-7.

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BACKGROUND: Striking geographic variations in prostate cancer incidence suggest an aetiological role for spatially-distributed factors. We assessed whether neighbourhood social deprivation, which can reflect limited social contacts, unfavourable lifestyle and environmental exposures, is associated with prostate cancer risk. METHODS: In 2005-2012, we recruited 1931 incident prostate cancer cases and 1994 controls in a case-control study in Montreal, Canada. Lifetime residential addresses were linked to an area-based social deprivation index around recruitment (2006) and about 10 years earlier (1996). Logistic regression estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Men residing in areas characterised by greater social deprivation had elevated prostate cancer risks (ORs of 1.54 and 1.60 for recent and past exposures, respectively; highest vs lowest quintiles), independently from area- and individual-level confounders and screening patterns. The increase in risk with recent high social deprivation was particularly elevated for high-grade prostate cancer at diagnosis (OR 1.87, 95% CI 1.32-2.64). Associations were more pronounced for neighbourhoods with higher proportions of separated/divorced or widowed individuals in the past, and with higher percentages of residents living alone recently. CONCLUSIONS: These novel findings, suggesting that neighbourhood-level social deprivation increases the risk of prostate cancer, point out to potential targeted public health interventions.

Type de document: Article
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 09 déc. 2023 18:12
Dernière modification: 10 déc. 2023 05:00
URI: https://espace.inrs.ca/id/eprint/13669

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