Dépôt numérique

The complicated lives of GPCRs in cardiac fibroblasts

Mazarura, Grace R; Dallagnol, Juliana C; Chatenet, David ORCID logoORCID: https://orcid.org/0000-0002-7270-4328; Allen, Bruce G. et Hébert, Terence E (2022). The complicated lives of GPCRs in cardiac fibroblasts American journal of physiology. Cell physiology , vol. 323 , nº 3. C813-C822. DOI: 10.1152/ajpcell.00120.2022.

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The role of different G protein-coupled receptors (GPCRs) in the cardiovascular system is well understood in cardiomyocytes and vascular smooth muscle cells (VSMCs). In the former, stimulation of Gs-coupled receptors leads to increases in contractility, whereas stimulation of Gq-coupled receptors modulates cellular survival and hypertrophic responses. In VSMCs, stimulation of GPCRs also modulates contractile and cell growth phenotypes. Here, we will focus on the relatively less well-studied effects of GPCRs in cardiac fibroblasts, focusing on key signaling events involved in the activation and differentiation of these cells. We also review the hierarchy of signaling events driving the fibrotic response and the communications between fibroblasts and other cells in the heart. We discuss how such events may be distinct depending on where the GPCRs and their associated signaling machinery are localized in these cells with an emphasis on nuclear membrane-localized receptors. Finally, we explore what such connections between the cell surface and nuclear GPCR signaling might mean for cardiac fibrosis.

Type de document: Article
Mots-clés libres: G protein-coupled receptors; G proteins; Cardiac fibrosis; Heart failure; Intracrine signaling
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 19 juill. 2023 05:01
Dernière modification: 19 juill. 2023 05:01
URI: https://espace.inrs.ca/id/eprint/13423

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