Lemay-St-Denis, Claudèle; Doucet, Nicolas 
ORCID: https://orcid.org/0000-0002-1952-9380 et Pelletier, Joelle N.
(2022).
Integrating dynamics into enzyme engineering
Protein Engineering, Design and Selection
, vol. 35
, nº gzac015.
pp. 1-11.
DOI: 10.1093/protein/gzac015.
Résumé
Enzyme engineering has become a widely adopted practice in research labs and industry. In parallel, the past decades have seen tremendous strides in characterizing the dynamics of proteins, using a growing array of methodologies. Importantly, links have been established between the dynamics of proteins and their function. Characterizing the dynamics of an enzyme prior to, and following, its engineering is beginning to inform on the potential of 'dynamic engineering', i.e., the rational modification of protein dynamics to alter enzyme function. Here we examine the state of knowledge at the intersection of enzyme engineering and protein dynamics, describe current challenges and highlight pioneering work in the nascent area of dynamic engineering.
| Type de document: | Article |
|---|---|
| Mots-clés libres: | Conformational landscape; Enzyme engineering; Molecular dynamics; Protein design; Protein motions |
| Centre: | Centre INRS-Institut Armand Frappier |
| Date de dépôt: | 25 juill. 2023 04:15 |
| Dernière modification: | 25 juill. 2023 04:15 |
| URI: | https://espace.inrs.ca/id/eprint/13413 |
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