Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell

Fuselier, Camille; Dufay, Eleonore; Berquand, Alexandre; Terryn, Cristine; Bonnomet, Arnaud; Molinari, Michael; Martiny, Laurent et Schneider, Christophe (2023). Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell Cell Adhesion & Migration , vol. 17 , nº 1. pp. 1-13. DOI: 10.1080/19336918.2022.2154732.

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Résumé

Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of Ruta Graveolens leads to an in vitro inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination in vivo. These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in in vitro and in vivo models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of Ruta graveolens and reinforce its interest as complementary medicine in oncology.

Type de document:	Article
Informations complémentaires:	F
Mots-clés libres:	Melanoma; Cancer; Dynamized ultra-low dilution; Migration; Plasma membrane
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	19 juill. 2023 05:08
Dernière modification:	19 juill. 2023 05:08
URI:	https://espace.inrs.ca/id/eprint/13384

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