Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell

Fuselier, Camille, Dufay, Eleonore, Berquand, Alexandre, Terryn, Cristine, Bonnomet, Arnaud, Molinari, Michael, Martiny, Laurent et Schneider, Christophe (2023). Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell Cell Adhesion & Migration , vol. 17 , nº 1. pp. 1-13. DOI: 10.1080/19336918.2022.2154732.

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Résumé

Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of Ruta Graveolens leads to an in vitro inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination in vivo. These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in in vitro and in vivo models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of Ruta graveolens and reinforce its interest as complementary medicine in oncology.

Type de document:	Article
Informations complémentaires:	F
Mots-clés libres:	Melanoma; Cancer; Dynamized ultra-low dilution; Migration; Plasma membrane
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	19 juill. 2023 05:08
Dernière modification:	19 juill. 2023 05:08
URI:	https://espace.inrs.ca/id/eprint/13384

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