Dépôt numérique

Colistin resistance mechanisms in Gram-negative bacteria: a Focus on Escherichia coli

Abavisani, Mohammad; Bostanghadiri, Narjess; Ghahramanpour, Hossein; Kodori, Mansoo; Akrami, Fariba; Fathizadeh, Hadis; Hashemi, Ali et Rastegari-Pouyani, Mohsen (2023). Colistin resistance mechanisms in Gram-negative bacteria: a Focus on Escherichia coli Letters in Applied Microbiology , vol. 76 , nº 2. pp. 1-13. DOI: 10.1093/lambio/ovad023.

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Multidrug-resistant (MDR) Escherichia coli strains have rapidly increased worldwide, and effective antibiotic therapeutic options are becoming more restricted. As a polymyxin antibiotic, colistin has a long history of usage, and it is used as a final line of treatment for severe infections by Gram-negative bacteria (GNB) with high-level resistance. However, its application has been challenged by the emergence of E. coli colistin resistance. Hence, determining the mechanism that confers colistin resistance is crucial for monitoring and controlling the dissemination of colistin-resistant E. coli strains. This comprehensive review summarizes colistin resistance mechanisms in E. coli strains and concentrates on the history, mode of action, and therapeutic implications of colistin. We have mainly focused on the fundamental mechanisms of colistin resistance that are mediated by chromosomal or plasmid elements and discussed major mutations in the two-component systems (TCSs) genes and plasmids that transmit the mcr resistant genes in E. coli strains.

Type de document: Article
Mots-clés libres: Escherichia coli; Mcr-genes; Gram-negative bacteria; Anibiotics resistance; Colistin
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 25 juill. 2023 04:11
Dernière modification: 25 juill. 2023 04:11
URI: https://espace.inrs.ca/id/eprint/13324

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