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Small RNAs beyond Model Organisms: Have We Only Scratched the Surface?

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Boutet, Émilie, Djerroud, Samia et Perreault, Jonathan ORCID: https://orcid.org/0000-0003-4726-6319 (2022). Small RNAs beyond Model Organisms: Have We Only Scratched the Surface? International Journal of Molecular Sciences , vol. 23 , nº 8:4448. p. 1-14. DOI: 10.3390/ijms23084448.

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Résumé

Small RNAs (sRNAs) are essential regulators in the adaptation of bacteria to environmental changes and act by binding targeted mRNAs through base complementarity. Approximately 550 distinct families of sRNAs have been identified since their initial characterization in the 1980s, accelerated by the emergence of RNA-sequencing. Small RNAs are found in a wide range of bacterial phyla, but they are more prominent in highly researched model organisms compared to the rest of the sequenced bacteria. Indeed, Escherichia coli and Salmonella enterica contain the highest number of sRNAs, with 98 and 118, respectively, with Enterobacteriaceae encoding 145 distinct sRNAs, while other bacteria families have only seven sRNAs on average. Although the past years brought major advances in research on sRNAs, we have perhaps only scratched the surface, even more so consider-ing RNA annotations trail behind gene annotations. A distinctive trend can be observed for genes, whereby their number increases with genome size, but this is not observable for RNAs, although they would be expected to follow the same trend. In this perspective, we aimed at establishing a more accurate representation of the occurrence of sRNAs in bacteria, emphasizing the potential for novel sRNA discoveries. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Type de document: Article
Mots-clés libres: Genetic Regulation; Non-Coding RNA; Small RNAs
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 10 juill. 2022 14:13
Dernière modification: 10 juill. 2022 14:13
URI: https://espace.inrs.ca/id/eprint/12747

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