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Accelerated synthesis of surface functionalized mannosylated dendrimers built on cyclotriphosphazene core

Sallam, Lamyaa M, Shiao, Tze Chieh, Sehad, Celia, Azzouz, Abdelkrim et Roy, René (2019). Accelerated synthesis of surface functionalized mannosylated dendrimers built on cyclotriphosphazene core MRS Advances , vol. 4 , nº 59-60. pp. 3187-3198. DOI: 10.1557/adv.2019.375.

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Résumé

The syntheses of five propargylated dendrimer scaffolds ranging from 2, 3, 4, 6, and 12 surface groups are described together with a 2-azidoethyl α-D-mannopyranoside. The former is appended to the core structure using highly efficient copper-catalysed azide-alkyne cycloaddition (CuAAC) (click reaction) to provide glycodendrimers in an accelerated approach. Two of the core structures are based on cyclotrisphosphazene, thus expanding the scope of the onion-peel strategy to build dendritic architectures with a large number of surface groups at the G1 generation only. © Materials Research Society 2019.

Type de document: Article
Mots-clés libres: Biomaterial; Chemical Synthesis; Nanostructure
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 30 juin 2022 14:09
Dernière modification: 30 juin 2022 14:09
URI: https://espace.inrs.ca/id/eprint/12439

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