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Accelerated synthesis of surface functionalized mannosylated dendrimers built on cyclotriphosphazene core

Sallam, Lamyaa M; Shiao, Tze Chieh; Sehad, Celia; Azzouz, Abdelkrim et Roy, René (2019). Accelerated synthesis of surface functionalized mannosylated dendrimers built on cyclotriphosphazene core MRS Advances , vol. 4 , nº 59-60. pp. 3187-3198. DOI: 10.1557/adv.2019.375.

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Résumé

The syntheses of five propargylated dendrimer scaffolds ranging from 2, 3, 4, 6, and 12 surface groups are described together with a 2-azidoethyl α-D-mannopyranoside. The former is appended to the core structure using highly efficient copper-catalysed azide-alkyne cycloaddition (CuAAC) (click reaction) to provide glycodendrimers in an accelerated approach. Two of the core structures are based on cyclotrisphosphazene, thus expanding the scope of the onion-peel strategy to build dendritic architectures with a large number of surface groups at the G1 generation only. © Materials Research Society 2019.

Type de document: Article
Mots-clés libres: Biomaterial; Chemical Synthesis; Nanostructure
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 30 juin 2022 14:09
Dernière modification: 30 juin 2022 14:09
URI: https://espace.inrs.ca/id/eprint/12439

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