Dépôt numérique

The implications of the purinergic signaling throughout pregnancy

Sagrillo-Fagundes, Lucas, Casagrande Paim, Thaís, Pretto, Luiza, Bertaco, Isabora, Zanatelli, Carla, Vaillancourt, Cathy ORCID: https://orcid.org/0000-0003-0543-6244 et Wink, Márcia R (2021). The implications of the purinergic signaling throughout pregnancy Journal of Cellular Physiology , vol. 237 , nº 1. p. 507-522. DOI: 10.1002/jcp.30594.

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Purinergic signaling is a necessary mechanism to trigger or even amplify cell communication. Its ligands, notably adenosine triphosphate (ATP) and adenosine, modulate specific membrane-bound receptors in virtually all human cells. Regardless of the stage of the pregnancy, cellular communication between maternal, placental, and fetal cells is the paramount mechanism to sustain its optimal status. In this review, we describe the crucial role of purinergic signaling on the regulation of the maternal-fetal trophic exchanges, immune control, and endocrine exchanges throughout pregnancy. The nature of the modulation of both ATP and adenosine on the embryo-maternal interface, going through placental invasion until birth delivery depends on the general maternal-fetal health state and consequently on the selective activation of their specific receptors. In addition, an increasing number of studies have been demonstrating the pivotal role of ATP and adenosine in modulating deleterious effects of suboptimal conditions of pregnancy. Here, we discuss the role of purinergic signaling on the balance that coordinates the embryo-maternal exchanges and a promising therapeutic venue in the context of pregnancy disorders.

Type de document: Article
Mots-clés libres: ATP; Adenosine; Embryo-Maternal Interface; Placenta; Pregnancy
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 30 juin 2022 14:09
Dernière modification: 30 juin 2022 14:09
URI: https://espace.inrs.ca/id/eprint/12437

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