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An epigenetic "extreme makeover": the methylation of flaviviral RNA (and beyond)


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Ruggieri, Alessia; Helm, Mark et Chatel-Chaix, Laurent ORCID logoORCID: https://orcid.org/0000-0002-7390-8250 (2020). An epigenetic "extreme makeover": the methylation of flaviviral RNA (and beyond) RNA Biology , vol. 18 , nº 5. pp. 696-708. DOI: 10.1080/15476286.2020.1868150.

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Beyond their high clinical relevance worldwide, flaviviruses (comprising dengue and Zika viruses) are of particular interest to understand the spatiotemporal control of RNA metabolism. Indeed, their positive single-stranded viral RNA genome (vRNA) undergoes in the cytoplasm replication, translation and encapsidation, three steps of the flavivirus life cycle that are coordinated through a fine-tuned equilibrium. Over the last years, RNA methylation has emerged as a powerful mechanism to regulate messenger RNA metabolism at the posttranscriptional level. Not surprisingly, flaviviruses exploit RNA epigenetic strategies to control crucial steps of their replication cycle as well as to evade sensing by the innate immune system. This review summarizes the current knowledge about vRNA methylation events and their impacts on flavivirus replication and pathogenesis. We also address the important challenges that the field of epitranscriptomics faces in reliably and accurately identifying RNA methylation sites, which should be considered in future studies on viral RNA modifications.

Type de document: Article
Mots-clés libres: 2ʹ-O-methylation; Flavivirus; N6-methyladenosine; RNA methylation; RNA modification; West Nile virus; Zika virus; cap; dengue virus; viral RNA
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 22 juin 2022 19:39
Dernière modification: 22 juin 2022 19:39
URI: https://espace.inrs.ca/id/eprint/12435

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