Dépôt numérique
RECHERCHER

Recent development in the design of small 'drug-like' and nanoscale glycomimetics against Escherichia coli infections

Mousavifar, Leila et Roy, René (2021). Recent development in the design of small 'drug-like' and nanoscale glycomimetics against Escherichia coli infections Drug Discovery Today , vol. 26 , nº 9. p. 2124-2137. DOI: 10.1016/j.drudis.2021.02.025.

Ce document n'est pas hébergé sur EspaceINRS.

Résumé

Glycoconjugates are involved in several pathological processes. Glycomimetics that can favorably emulate complex carbohydrate structures, while competing with natural ligands as inhibitors, are gaining considerable attention owing to their improved hydrolytic stability, binding affinity, and pharmacokinetic (PK) properties. Of particular interest are the families of α-D-mannopyranoside analogs, which can be used as inhibitors against adherent invasive Escherichia coli infections. Bacterial resistance to modern antibiotics triggers the search for new alternative antibacterial strategies that are less susceptible to acquiring resistance. In this review, we highlight recent progress in the chemical syntheses of this family of compounds, one of which having reached clinical trials against Crohn's disease (CD).

Type de document: Article
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 23 juin 2022 02:38
Dernière modification: 23 juin 2022 02:38
URI: https://espace.inrs.ca/id/eprint/12402

Actions (Identification requise)

Modifier la notice Modifier la notice