Dépôt numérique

The role of the DFF40/CAD endonuclease in genomic stability

Kulbay, Merve; Bernier-Parker, Nathan et Bernier, Jacques ORCID logoORCID: https://orcid.org/0000-0002-0594-5922 (2021). The role of the DFF40/CAD endonuclease in genomic stability Apoptosis , vol. 26 , nº 1-2. pp. 9-23. DOI: 10.1007/s10495-020-01649-7.

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Maintenance of genomic stability in cells is primordial for cellular integrity and protection against tumor progression. Many factors such as ultraviolet light, oxidative stress, exposure to chemical reagents, particularly mutagens and radiation, can alter the integrity of the genome. Thus, human cells are equipped with many mechanisms that prevent these irreversible lesions in the genome, as DNA repair pathways, cell cycle checkpoints, and telomeric function. These mechanisms activate cellular apoptosis to maintain DNA stability. Emerging studies have proposed a new protein in the maintenance of genomic stability: the DNA fragmentation factor (DFF). The DFF40 is an endonuclease responsible of the oligonucleosomal fragmentation of the DNA during apoptosis. The lack of DFF in renal carcinoma cells induces apoptosis without oligonucleosomal fragmentation, which poses a threat to genetic information transfer between cancerous and healthy cells. In this review, we expose the link between the DFF and genomic instability as the source of disease development. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

Type de document: Article
Mots-clés libres: Apoptosis; Cancer Cell Resistance; DFF40; Genomic Stability
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 23 juin 2022 02:30
Dernière modification: 23 juin 2022 02:30
URI: https://espace.inrs.ca/id/eprint/12366

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