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Disease-Specific Extracellular Matrix Composition Influences Placental Trophoblast Fusion

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Parameshwar, Prabu Karthick; Sagrillo-Fagundes, Lucas; Girard, Sylvie; Vaillancourt, Cathy et Moraes, Christopher . Disease-Specific Extracellular Matrix Composition Influences Placental Trophoblast Fusion In: Biomedical engineering society (BMES), 14-17 October 2020, virtuel.

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Introduction: The placenta plays a critical regulatory role in short- and long-term maternal and fetal health during pregnancy. In humans, transport of nutrients and waste is regulated through the syncytiotrophoblast, a giant multinucleated cell formed and maintained through fusion of mononuclear cytotrophoblasts. Despite the established importance of maintaining a syncytiotrophoblast for healthy pregnancies, the in vivo factors regulating cytotrophoblast fusion are not well defined, and understanding these factors are critical to develop tissue engineered placental models and novel therapeutic strategies for placental disorders. We have previously established that extracellular matrix (ECM) mechanics and architecture play an important role in regulating fusion (1,2), and here, we investigate whether the composition of disease-specific ECM further regulates cell fusion..

Type de document: Document issu d'une conférence ou d'un atelier
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Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 14 juill. 2021 16:03
Dernière modification: 14 juill. 2021 16:03
URI: https://espace.inrs.ca/id/eprint/11834

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