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3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) derivatives in antibacterial drug discovery

Cloutier, Maude et Gauthier, Charles ORCID: https://orcid.org/0000-0002-2475-2050 (2020). 3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) derivatives in antibacterial drug discovery In: Carbohydrates in Drug Discovery and Development: Synthesis and Application. Elsevier, Cambridge, MA, p. 155-212.

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Résumé

The re-emergence of pathogenic bacteria and their growing resistance to currently used antibiotics has prompted the search for new therapeutic targets and antibiotics. As a highly conserved and essential element of Gram-negative bacteria lipopolysaccharides (LPS), 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) biosynthesis is an exquisite target for the development of new therapeutics. Indeed, as loss of functional Kdo-processing enzymes has been shown to affect cell viability and/or virulence, there is a growing interest in the discovery of potential inhibitors of this enzymatic pathway. In past years, not only has there been tremendous progress in the total synthesis of Kdo, but a variety of Kdo derivatives have been developed as potential inhibitors of Kdo-processing enzymes as well as for the metabolic glycan LPS labeling of living organisms. This book chapter aims at covering the progresses in the total synthesis of Kdo and its derivatives.

Type de document: Chapitre de livre
Mots-clés libres: Gram-negative bacteria; lipopolysaccharide; capsular polysaccharide; exopolysaccharide; Kdo; glycosyltransferase; inhibitor; metabolic glycan labeling
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 14 juill. 2021 15:52
Dernière modification: 15 févr. 2022 17:32
URI: https://espace.inrs.ca/id/eprint/11824

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