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Synthesis of oligosaccharides related to potential bioterrorist pathogens

Cloutier, Maude, Muru, Kevin et Gauthier, Charles ORCID: https://orcid.org/0000-0002-2475-2050 (2020). Synthesis of oligosaccharides related to potential bioterrorist pathogens In: Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical Applications of Glycans and Glycoconjugates. Elsevier, Cambridge, MA, p. 143-206.

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Résumé

Bioterrorism is seen as a serious threat in today’s world. Some bacterial pathogens have been listed as potential bioterrorism agents due to their low infectious doses, ability to be aerosolized, high transmission rate, and tolerance to a wide range of environmental conditions. This list includes the CDC Tier 1 Select Agents Bacillus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia pseudomallei, and Burkholderia mallei. Gram-negative pathogenic Brucella spp., even if not on this list, are also of interest as brucellosis is considered to be one of the most neglected zoonoses. These bacteria are producing highly immunogenic polysaccharides at their surface, which act as exquisite antigens for the development of vaccines and diagnostic tools. In past years, a number of oligosaccharides related to these potential bioterrorist pathogens have been synthesized. This book chapter aims at covering the recent developments in this important field from the perspective of the carbohydrate chemist.

Type de document: Chapitre de livre
Mots-clés libres: Gram-negative bacteria; Bioterrorism agents; Oligosaccharide synthesis; Glycosylation
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 14 juill. 2021 15:51
Dernière modification: 15 févr. 2022 17:31
URI: https://espace.inrs.ca/id/eprint/11823

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