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Periphery-confined particulate systems for the management of neurodegenerative diseases and toxicity: Avoiding the blood-brain-barrier challenge

Rabanel, Jean-Michel, Delbreil, Philippe, Banquy, Xavier, Brambilla, Davide et Ramassamy, Charles ORCID: https://orcid.org/0000-0002-3252-5878 (2020). Periphery-confined particulate systems for the management of neurodegenerative diseases and toxicity: Avoiding the blood-brain-barrier challenge Journal of Controlled Release , vol. 322 . p. 286-299. DOI: 10.1016/j.jconrel.2020.03.035.

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Résumé

The blood-brain barrier prevents passage of large and hydrophilic molecules, undermining efforts to deliver most active molecules, proteins and other macromolecules. To date, nanoparticle-assisted delivery has been extensively studied to overcome this challenge but with limited success. On the other hand, for certain brain therapeutic applications, periphery-confined particles could be of immediate therapeutic usefulness. The modulation of CNS dysfunctions from the peripheral compartment is a promising approach, as it does not involve invasive interventions. From recent studies, three main roles could be identified for periphery-confined particles: brain tissue detoxification via the "sink-effect"; a "circulating drug-reservoir" effect to improve drug delivery to brain tissues, and finally, brain vascular endothelium targeting to diagnose or heal vascular-related dysfunctions. These applications are much easier to implement as they do not involve complex therapeutic and targeting strategies and do not require crossing biological barriers. Micro/nano-devices required for such applications will likely be simpler to synthesize and will involve fewer complex materials. Moreover, peripheral particles are expected to be less prone to neurotoxicity and issues related to their diffusion in confined space.

Type de document: Article
Mots-clés libres: Circulating particles; Drug reservoir effect; Nanoparticle; Periphery-confined particulate systems; Sink-effect; Vascular endothelium targeting
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 20 juill. 2021 21:28
Dernière modification: 15 févr. 2022 21:25
URI: https://espace.inrs.ca/id/eprint/11669

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