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Serine Protease Autotransporters of the Enterobacteriaceae (SPATEs): Out and About and Chopping It Up


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Pokharel, Parvil; Habouria, Hajer; Bessaiah, Hicham et Dozois, Charles M. ORCID logoORCID: https://orcid.org/0000-0003-4832-3936 (2019). Serine Protease Autotransporters of the Enterobacteriaceae (SPATEs): Out and About and Chopping It Up Microorganisms , vol. 7 , nº 12:594. pp. 1-27. DOI: 10.3390/microorganisms7120594.

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Autotransporters are secreted proteins with multiple functions produced by a variety of Gram-negative bacteria. In Enterobacteriaceae, a subgroup of these autotransporters are the SPATEs (serine protease autotransporters of Enterobacteriaceae). SPATEs play a crucial role in survival and virulence of pathogens such as Escherichia coli and Shigella spp. and contribute to intestinal and extra-intestinal infections. These high molecular weight proteases are transported to the external milieu by the type Va secretion system and function as proteases with diverse substrate specificities and biological functions including adherence and cytotoxicity. Herein, we provide an overview of SPATEs and discuss recent findings on the biological roles of these secreted proteins, including proteolysis of substrates, adherence to cells, modulation of the immune response, and virulence in host models. In closing, we highlight recent insights into the regulation of expression of SPATEs that could be exploited to understand fundamental SPATE biology.

Type de document: Article
Mots-clés libres: E. coli; adhesins; autotransporters; cytotoxins; gene regulation; serine protease autotransporters of Enterobacteriaceae (SPATE)
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 20 juill. 2021 21:47
Dernière modification: 15 févr. 2022 15:40
URI: https://espace.inrs.ca/id/eprint/11665

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