Impact of palladium nanoparticles (Pd-NPs) on the biology of neutrophils in vitro and on leukocyte attraction in vivo

Kwemo, Pierrette, Saafane, Abdelaziz, Vanharen, Marion, Durocher, Isabelle et Girard, Denis ORCID: https://orcid.org/0000-0002-3342-5027 (2020). Impact of palladium nanoparticles (Pd-NPs) on the biology of neutrophils in vitro and on leukocyte attraction in vivo Journal of Nanoparticle Research , vol. 22 , nº 350. p. 1-11. DOI: 10.1007/s11051-020-05079-z.

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Résumé

Recently, palladium nanoparticles (Pd-NPs) have been shown to possess pro-inflammatory activities. Herein, we investigated potential in vitro effects of Pd-NPs (primary size of 1–10 nm) on the biology of neutrophils, key player cells in inflammation. Also, the aim of this study was to evaluate the pro-inflammatory activity of Pd-NPs using the murine air pouch model, a model previously proposed to be used as a standard assay for testing in vivo pro-inflammatory effects of NPs. Although the positive controls used in vitro give the expected results in all biological functions tested, Pd-NPs do not affect the production of reactive oxygen species and that of interleukin-1β (IL-1β), IL-6, and IL-8. Pd-NPs moderately increase cellular adhesion of neutrophils onto human endothelial cells and significantly increase the capacity of neutrophils to migrate and to delay apoptosis. We conclude that Pd-NPs possess some pro-inflammatory activity in vitro but do not attract leukocytes in vivo regardless of sex.

Type de document:	Article
Mots-clés libres:	-
Centre:	Centre INRS-Institut Armand Frappier
Date de dépôt:	20 juill. 2021 04:13
Dernière modification:	04 nov. 2022 20:10
URI:	https://espace.inrs.ca/id/eprint/11615

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