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Towards the optimization of botanical insecticides research: Aedes aegypti larvicidal natural products in French Guiana

Falkowski, Michael, Jahn-Oyac, Arnaud, Odonne, Guillaume, Flora, Claudiane, Estevez, Yannick, Toure, Seindé, Boulogne, Isabelle, Robinson, Jean-Charles, Bereau, Didier, Petit, Philippe, Azam, Didier, Coke, Maïra, Issaly, Jean, Gaborit, Pascal, Stien, Didier, Eparvier, Véronique, Dusfour, Isabell et Houel, Emline (2020). Towards the optimization of botanical insecticides research: Aedes aegypti larvicidal natural products in French Guiana Acta Tropica , vol. 201 , nº 105179. p. 1-12. DOI: 0.1016/j.actatropica.2019.105179.

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Résumé

Natural products have proven to be an immeasurable source of bioactive compounds. The exceptional biodiversity encountered in Amazonia, alongside a rich entomofauna and frequent interactions with various herbivores is the crucible of a promising chemodiversity. This prompted us to search for novel botanical insecticides in French Guiana. As this French overseas department faces severe issues linked to insects, notably the strong incidence of vector-borne infectious diseases, we decided to focus our research on products able to control the mosquito Aedes aegypti. We tested 452 extracts obtained from 85 species originating from 36 botanical families and collected in contrasted environments against an Aedes aegypti laboratory strain susceptible to all insecticides, and a natural population resistant to both pyrethroid and organophosphate insecticides collected in Cayenne for the most active of them. 8 species (Maytenus oblongata Reissek, Celastraceae; Costus erythrothyrsus Loes., Costaceae; Humiria balsamifera Aubl., Humiriaceae; Sextonia rubra (Mez) van der Werff, Lauraceae; Piper hispidum Sw., Piperaceae; Laetia procera (Poepp.) Eichl., Salicaceae; Matayba arborescens (Aubl.) Radlk., Sapindaceae; and Cupania scrobitulata Rich., Sapindaceae) led to extracts exhibiting more than 50% larval mortality after 48h of exposition at 100 microg/mL against the natural population and were considered active. Selectivity and phytochemistry of these extracts were therefore investigated and discussed, and some active compounds highlighted. Multivariate analysis highlighted that solvents, plant tissues, plant family and location had a significant effect on mortality while light, available resources and vegetation type did not. Through this case study we highlighted that plant defensive chemistry mechanisms are crucial while searching for novel insecticidal products.

Type de document: Article
Mots-clés libres: Amazonian chemodiversity; Chemical defense; Culicidae; Mosquito larvicides; Quasi-Poisson generalized linear model; Screening optimization
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 20 juill. 2021 03:57
Dernière modification: 20 juill. 2021 03:57
URI: https://espace.inrs.ca/id/eprint/11581

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