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Synthesis and Biological Activity of Hydrazones and Derivatives: A Review

Brum, Juliana de Oliveira Carneiro; Franca, Tanos Celmar Costa; Laplante, Steven ORCID logoORCID: https://orcid.org/0000-0003-2835-5789 et Villar, José Daniel Figueroa (2020). Synthesis and Biological Activity of Hydrazones and Derivatives: A Review Mini-Reviews in Medicinal Chemistry , vol. 20 , nº 5. pp. 342-368. DOI: 10.2174/1389557519666191014142448.

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Hydrazones and their derivatives are very important compounds in medicinal chemistry due to their reported biological activity for the treatment of several diseases, like Alzheimer's, cancer, inflammation, and leishmaniasis. However, most of the investigations on hydrazones available in literature today are directed to the synthesis of these molecules with little discussion available on their biological activities. With the purpose of bringing lights into this issue, we performed a revision of the literature and wrote this review based on some of the most current research reports of hydrazones and derivatives, making it clear that the synthesis of these molecules can lead to new drug prototypes. Our goal is to encourage more studies focused on the synthesis and evaluation of new hydrazones, as a contribution to the development of potential new drugs for the treatment of various diseases.

Type de document: Article
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 15 juill. 2021 00:50
Dernière modification: 15 févr. 2022 18:47
URI: https://espace.inrs.ca/id/eprint/11554

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