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HIV modifies the effect of tobacco smoking on oral human papillomavirus infection

Alli, Babatunde Y, Burk, Robert D, Fatahzadeh, Mahnaz, Grossberg, Robert M, Smith, Richard V, Ow, Thomas J, Wiltz, Mauricio, Polanco, Jacqueline, Rousseau, Marie-Claude ORCID: https://orcid.org/0000-0001-5215-8086, Nicolau, Belinda et Schlecht, Nicolas F (2020). HIV modifies the effect of tobacco smoking on oral human papillomavirus infection Journal of Infectious Diseases , vol. 222 , nº 4. p. 646-654. DOI: 10.1093/infdis/jiaa135.

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Résumé

INTRODUCTION:

People living with HIV (PLWH) are more likely to smoke and harbor oral human papillomavirus (HPV) infections, putting them at higher risk for head and neck cancer. We sought to investigate the joint effects of HIV and smoking on risk of oral HPV.

METHODS:

Consecutive PLWH (n=169) and at-risk HIV-negative individuals (n=126) were recruited from two large health centers in United States. Lifetime smoking history was collected using questionnaires. Participants provided oral rinse samples for HPV genotyping by Next-Generation Sequencing. We used multivariable logistic regression models with interaction terms for HIV to test for smoking effect on oral HPV and reported the Relative Excess Risk due to Interaction (RERI).

RESULTS:

PLWH were more likely to harbor oral HPV than HIV-negative individuals, including alpha (39% vs. 28%), beta (73% vs. 63%), and gamma-types (33% vs. 20%). HIV infection positively modified the association between smoking and detection of high-risk oral HPV with odds ratios for smoking of 3.46 [95%CI:1.01, 11.94] and 1.59 [95%CI:0.32, 8.73] among PLWH and HIV-negative individuals, respectively, and an observed RERI of 3.34 [95%CI:-1.51, 8.18]. The RERI for HPV-16 was 1.79 [95%CI:-2.57, 6.16], and 2.78 for beta1-HPV [95%CI:-0.08, 5.65].

CONCLUSION:

Our results show tobacco smoking as a risk factor for oral HPV among PLWH.

Type de document: Article
Mots-clés libres: HIV; HPV; smoking; tobacco
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 15 juill. 2021 00:58
Dernière modification: 16 févr. 2022 14:58
URI: https://espace.inrs.ca/id/eprint/11531

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