Document quand l'auteur est "Laplante, Steven"

Botelho, Fernanda Diniz; Franca, Tanos Celmar Costa et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2024). The Search for Antidotes Against Ricin Mini-Reviews in Medicinal Chemistry . DOI: 10.2174/0113895575270509231121060105. (Sous Presse)

Ali, Zeeshan; Cardoza, Jyothsna Volisha; Basak, Srijita; Narsaria, Utkarsh; Bhattacharjee, Surjit; G, Unnati Meher; Isaac, Samuel Paul; Franca, Tanos Celmar Costa; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 et George, Sudhan S (2023). A Multi-epitope Vaccine Candidate Against Bolivian Hemorrhagic fever Caused by Machupo Virus Applied biochemistry and biotechnology . DOI: 10.1007/s12010-023-04604-9. (Sous Presse)

Mendes dos Santos, Eduardo; do Amaral e Silva, Nayane Abreu; Gonçalves, Karina Godarth; Vale, André Alvares Marques; de Azevedo-Santos, Ana Paula Silva; Franca, Tanos Celmar Costa; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Resende, Jackson Antonio Lamounier Camargos; Romeiro, Nelilma Correia; Lima, Josélia Alencar; Martins, Daniela de Luna et Nascimento, Maria do Desterro Soares Brandão (2023). Arylboronic acids as safe and specific human butyrylcholinesterase inhibitors Journal of Molecular Structure , vol. 1290 , nº 135932. pp. 1-14. DOI: 10.1016/j.molstruc.2023.135932.

AliYas, Zeinaib; Cardoza, Jyothsna Volisha; Basak, Srijita; Narsaria, Utkarsh; Singh, Vijay P.; Isaac, Samuel Paul; Franca, Tanos Celmar Costa; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 et George, Sudhan S. (2023). Computational design of candidate multi-epitope vaccine against SARS-CoV-2 targeting structural (S and N) and non-structural (NSP3 and NSP12) proteins Journal of Biomolecular Structure and Dynamics , vol. 41 , nº 22. pp. 13348-13367. DOI: 10.1080/07391102.2023.2173297. (Sous Presse)

Franca, Tanos Celmar Costa; Goncalves, Arlan da Silva; Berube, Christopher; Voyer, Normand; Aubry, Norman et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2023). Determining the Predominant Conformations of Mortiamides A-D in Solution Using NMR Data and Molecular Modeling Tools ACS Omega , vol. 8 , nº 29. pp. 25832-25838. DOI: 10.1021/acsomega.3c01206.

Fnaiche, Ahmed; Mélin, Léa; Suárez, Narjara González; Paquin, Alexis; Vu, Victoria; Li, Fengling; Allali-Hassani, Abdellah; Bolotokova, Albina; Allemand, Frédéric; Gelin, Muriel; Cotelle, Philippe; Woo, Simon; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Barsyte-Lovejoy, Dalia; Santhakumar, Vijayaratnam; Vedadi, Masoud; Guichou, Jean-François; Annabi, Borhane et Gagnon, Alexandre (2023). Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings Bioorganic & medicinal chemistry letters , vol. 95 , nº 129488. pp. 1-8. DOI: 10.1016/j.bmcl.2023.129488.

Shahout, Fatma; Vanharen, Marion; Saafane, Abdelaziz; Gillard, James; Girard, Denis ORCID: https://orcid.org/0000-0002-3342-5027 et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2023). Drug Self-Aggregation into Nano-Entities Has the Potential to Induce Immune Responses Molecular pharmaceutics , vol. 20 , nº 8. pp. 4031-4040. DOI: 10.1021/acs.molpharmaceut.3c00196.

Franca, Tanos Celmar Costa; Saidi, Fares; Ajamian, Alain; Islam, Salim Timo ORCID: https://orcid.org/0000-0001-6853-8446 et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2023). Molecular Dynamics of Outer Membrane-Embedded Polysaccharide Secretion Porins Reveals Closed Resting-State Surface Gates Targetable by Virtual Fragment Screening for Drug Hotspot Identification ACS Omega , vol. ahead , nº 3c09970. DOI: 10.1021/acsomega.3c09970. (Sous Presse)

Vieira, Leandro A; Almeida, Joyce S F D; De Koning, Martijn C; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Borges, Itamar et Franca, Tanos Celmar Costa (2023). Molecular modeling of Mannich phenols as reactivators of human acetylcholinesterase inhibited by A-series nerve agents Chemico-biological interactions , vol. 382 , nº 110622. pp. 1-13. DOI: 10.1016/j.cbi.2023.110622.

Ribeiro, Rayssa; Botelho, Fernanda D; Pinto, Amanda M V; La Torre, Antonia M A; Almeida, Joyce S F D; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Franca, Tanos Celmar Costa; Veiga, Valdir F et dos Santos, Marcelo C (2023). Molecular modeling study of natural products as potential bioactive compounds against SARS-CoV-2 Journal of Molecular Modeling , vol. 29 , nº 6. pp. 1-9. DOI: 10.1007/s00894-023-05586-5.

Sow, Aïssatou Aïcha; Pahmeier, Felix; Ayotte, Yann; Anton, Anaïs; Mazeaud, Clément; Charpentier, Tania; Angelo, Léna; Woo, Simon; Cerikan, Berati; Falzarano, Darryl; Abrahamyan, Levon; Lamarre, Alain ORCID: https://orcid.org/0000-0002-7913-871X; Labonté, Patrick ORCID: https://orcid.org/0000-0001-7262-3125; Cortese, Mirko; Bartenschlager, Ralf; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 et Chatel-Chaix, Laurent ORCID: https://orcid.org/0000-0002-7390-8250 (2023). N-Phenylpyridine-3-Carboxamide and 6-Acetyl-1H-Indazole Inhibit the RNA Replication Step of the Dengue Virus Life Cycle Antimicrobial Agents and Chemotherapy , vol. 67 , nº 2. pp. 1-14. DOI: 10.1128/aac.01331-22.

Larda, Sacha T; Ayotte, Yann; Denk, Maria M; Coote, Paul; Heffron, Gregory; Bendahan, David; Shahout, Fatma; Girard, Nicolas; Iddir, Mustapha; Bouchard, Patricia; Bilodeau, François; Woo, Simon; Farmer, Luc J et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2023). Robust Strategy for Hit-to-Lead Discovery: NMR for SAR Journal of medicinal chemistry , vol. 66 , nº 19. pp. 13416-13427. DOI: 10.1021/acs.jmedchem.3c00656.

Santos, Marcelo C; Botelho, Fernanda D; da Silva Goncalves, Arlan; Kitagawa, Daniel A S; Borges, Caio V N; Carvalho-Silva, Taynara; Bernardo, Leandro B; Ferreira, Cintia N; Rodrigues, Rafael B; Ferreira Neto, Denise C; Nepovimova, Eugenie; Kuca, Kamil; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Lima, Antoni L S; Franca, Tanos Celmar Costa et Cavalcante, Samir F A (2022). Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series? Archives of Toxicology , vol. 96 , nº 9. pp. 2259-2572. DOI: 10.1007/s00204-022-03316-z. (Sous Presse)

Farahani, Majid D; Franca, Tanos Celmar Costa; Alapour, Saba; Shahout, Fatma; Boulon, Richard; Iddir, Mustapha; Maddalena, Michael; Ayotte, Yann et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2022). Jumping From Fragment To Drug Via Smart Scaffolds ChemMedChem , vol. 17 , nº 10:e2022. pp. 1-8. DOI: 10.1002/cmdc.202200092.

Aghamohammadi, Mohammad; Sirouspour, Mehdi; Goncalves, Arlan S; Franca, Tanos Celmar Costa; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 et Shahdousti, Parvin (2022). Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19 Journal of Molecular Modeling , vol. 28 , nº 380. pp. 1-10. DOI: 10.1007/s00894-022-05356-9.

Ayotte, Yann; Woo, Simon et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2022). Practical Considerations and Guidelines for Spectral Referencing for Fluorine NMR Ligand Screening ACS Omega , vol. 7 , nº 15. pp. 13155-13163. DOI: 10.1021/acsomega.2c00613.

Franca, Tanos Celmar Costa; Botelho, Fernando D.; Drummond, Michael L. et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2022). Theoretical Investigation of Repurposed Drugs Potentially Capable of Binding to the Catalytic Site and the Secondary Binding Pocket of Subunit A of Ricin Acs Omega , vol. 7 , nº 36. pp. 32805-32815. DOI: 10.1021/acsomega.2c04819.

Mélin, Léa; Abdullayev, Shuay; Fnaiche, Ahmed; Vu, Victoria; González Suárez, Narjara; Zeng, Hong; Szewczyk, Magdalena; Li, Fengling; Senisterra, Guillermo; Allali-Hassani, Abdellah; Chau, Irene; Dong, Aiping; Woo, Simon; Annabi, Borhane; Halabelian, Levon; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Vedadi, Masoud; Barsyte-Lovejoy, Dalia; Santhakumar, Vijayaratnam et Gagnon, Alexandre (2021). Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid ChemMedChem , vol. 16 , nº 19. pp. 2982-3002. DOI: 10.1002/cmdc.202100432.

Ayotte, Yann; Bernet, Eve; Bilodeau, François; Cimino, Mena; Gagnon, Dominic; Lebughe, Marthe; Mistretta, Maxime; Ogadinma, Paul; Ouali, Sarah-Lisa; Sow, Aïssatou Aïcha; Chatel-Chaix, Laurent ORCID: https://orcid.org/0000-0002-7390-8250; Descoteaux, Albert ORCID: https://orcid.org/0000-0002-0633-5309; Manina, Giulia; Richard, Dave; Veyrier, Frédéric ORCID: https://orcid.org/0000-0002-8574-0547 et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2021). Fragment-Based Phenotypic Lead Discovery To Identify New Drug Seeds That Target Infectious Diseases ACS Chemical Biology , vol. 16 , nº 11. pp. 2158-2163. DOI: 10.1021/acschembio.1c00657.

Botelho, Fernanda D; Santos, Marcelo C; da Silva Goncalves, Arlan; Franca, Tanos Celmar Costa; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 et de Almeida, Joyce S F D (2021). Identification of novel potential ricin inhibitors by virtual screening, molecular docking, molecular dynamics and MM-PBSA calculations: a drug repurposing approach Journal of Biomolecular Structure and Dynamics . DOI: 10.1080/07391102.2020.1870154. (Sous Presse)

Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Roux, Valérie; Shahout, Fatma; LaPlante, Gabriela; Woo, Simon; Denk, Maria M; Larda, Sacha et Ayotte, Yann (2021). Probing the free-state solution behavior of drugs and their tendencies to self-aggregate into nano-entities Nature Protocols , vol. 16 , nº 11. pp. 5250-5273. DOI: 10.1038/s41596-021-00612-3.

Almeida, Joyce S F D; Botelho, Fernanda D; de Souza, Felipe R.; Dos Santos, Marcelo C.; da Silva Goncalves, Arlan; Rodrigues, Rodrigo L B; Cardozo, Monique; Kitagawa, Daniel A S; Vieira, Leandro A; Silva, Raphael S F; Cavalcante, Samir F A; Bastos, Leonardo da C; Nogueira, Mariana de O T; de Santana, Priscila I R; Brum, Juliana de Oliveira Carneiro; Nepovimova, Eugenie; Kuca, Kamil; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Galante, Erick B. F. et Franca, Tanos Celmar Costa (2021). Searching for potential drugs against SARS-CoV-2 through virtual screening on several molecular targets Journal of Biomolecular Structure and Dynamics . pp. 1-14. DOI: 10.1080/07391102.2020.1869096. (Sous Presse)

Bernet, Eve; Lebughe, Marthe; Vincent, Antony T.; Haghdoost, Mohammad Mehdi; Golbaghi, Golara; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Castonguay, Annie ORCID: https://orcid.org/0000-0001-5705-6353 et Veyrier, Frédéric ORCID: https://orcid.org/0000-0002-8574-0547 (2021). Sodium tetraphenylborate displays selective bactericidal activity against N. meningitidis and N. gonorrhoeae and is effective at reducing bacterial infection load Antimicrobial Agents and Chemotherapy , vol. 65 , nº 2. pp. 1-14. DOI: 10.1128/AAC.00254-20.

Simard, Jean-Christophe; Thibodeau, Jean-François; Leduc, Martin; Tremblay, Mikael; Laverdure, Alexandre; Sarra-Bournet, Francois; Gagnon, William; Ouboudinar, Jugurtha; Gervais, Liette; Felton, Alexandra; Letourneau, Sylvie; Geerts, Lilianne; Cloutier, Marie-Pier; Hince, Kathy; Corpuz, Ramon; Blais, Alexandra; Marques Quintela, Vanessa; Duceppe, Jean-Simon; Abbott, Shaun D; Blais, Amélie; Zacharie, Boulos; Laurin, Pierre; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Kennedy, Christopher R J; Hébert, Richard L; Leblond, François A.; Grouix, Brigitte et Gagnon, Lyne (2020). Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease Scientific Reports , vol. 10 , nº 12778. pp. 1-16. DOI: 10.1038/s41598-020-69675-8.

Botelho, Fernanda D; Dos Santos, Marcelo C.; da Silva Goncalves, Arlan; Kuca, Kamil; Valis, Martin; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Franca, Tanos Celmar Costa et de Almeida, Joyce S F D (2020). Ligand-Based Virtual Screening, Molecular Docking, Molecular Dynamics, and MM-PBSA Calculations towards the Identification of Potential Novel Ricin Inhibitors. Toxins , vol. 12 , nº e746. pp. 1-14. DOI: 10.3390/toxins12120746.

Pandey, Aditya; Larda, Sacha; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 et Prosser, Robert Scott (2020). NMR-based approaches to the study of GPCRs and GPCR-ligand interactions In: GPCRs: Structure, Function, and Drug Discovery. Elsevier, Cambridge, MA, pp. 65-80.

Valle da Silva, Jorge Alberto; Pereira, Ander Francisco; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Kuca, Kamil; Ramalho, Teodorico Castro et Franca, Tanos Celmar Costa (2020). Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study Biomolecules , vol. 10 , nº 2:192. pp. 1-8. DOI: 10.3390/biom10020192.

Wypych, Rachel M; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; White, Peter W et Martin, Stephen F (2020). Structure-thermodynamics-relationships of hepatitis C viral NS3 protease inhibitors European Journal of Medicinal Chemistry , vol. 192 , nº 112195. pp. 1-9. DOI: 10.1016/j.ejmech.2020.112195.

Brum, Juliana de Oliveira Carneiro; Franca, Tanos Celmar Costa; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 et Villar, José Daniel Figueroa (2020). Synthesis and Biological Activity of Hydrazones and Derivatives: A Review Mini-Reviews in Medicinal Chemistry , vol. 20 , nº 5. pp. 342-368. DOI: 10.2174/1389557519666191014142448.

Dlim, Marwa; Shahout, Fatma; Khabir, Marwa; Labonté, Patrick ORCID: https://orcid.org/0000-0001-7262-3125 et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2019). Revealing Drug Self-Associations into Nano-Entities ACS Omega , vol. 4 , nº 5. pp. 8919-8925. DOI: 10.1021/acsomega.9b00667.

Leroy, Maxime; Mélin, Léa; Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789; Medina-Franco, José L. et Gagnon, Alexandre (2019). Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity Bioorganic & Medicinal Chemistry Letters , vol. 26 , nº 6. pp. 826-831. DOI: 10.1016/j.bmcl.2019.01.022.

Ayotte, Yann; Marando, Victoria; Vaillancourt, Louis; Bouchard, Patricia; Heffron, Gregory; Coote, Paul W.; Larda, Sacha et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2019). Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay Journal of medicinal chemistry , vol. 62 , nº 17. pp. 7885-7896. DOI: 10.1021/acs.jmedchem.9b00653.

Murugesan, Jayadeepa R.; Shahout, Fatma; Dlim, Marwa; Langella, M. Michele; Cuadra-Foy, Ernesto; Forgione, Pat et Laplante, Steven ORCID: https://orcid.org/0000-0003-2835-5789 (2018). Revealing dye and dye-drug aggregation into nano-entities using NMR Dyes and Pigments , vol. 153 . pp. 300-306. DOI: 10.1016/j.dyepig.2018.02.026.

Oguadinma, Paul; Bilodeau, François et Laplante, Steven (2017). NMR strategies to support medicinal chemistry workflows for primary structure determination Bioorganic and Medicinal Chemistry Letters , vol. 27 , nº 2. pp. 242-247. DOI: 10.1016/j.bmcl.2016.11.066.

Ayotte, Yann; Murugesan, Jayadeepa R.; Bilodeau, François; Larda, Sacha; Bouchard, Patricia; Drouin, Nathalie; Morin, Melissa et Laplante, Steven (2017). Discovering Quality Drug Seeds by Practical NMR-based Fragment Screening In: 31st Annual Symposium of the Protein-Society, July 24-27, 2017, Montréal (Québec) Canada.

Laplante, Steven et Bilodeau, François (2016). The Rise of Academia-Pharma Partnerships for Discovering New Chemical Matter for Future Drugs EC Microbiology , vol. 4 , nº 5. pp. 756-778.

Laplante, Steven . Atropisomer axial chirality as a valuable tool in drug discovery In: 255th National Meeting and Exposition of the American-Chemical-Society (ACS), 18-22 Mars 2018, New Orleans.

Ayotte, Yann; Murugesan, Jayadeepa R.; Fortier, Marlène; St-Pierre, Yves et Laplante, Steven . Criblage de fragments par RMN afin de découvrir des molécules ciblant la galectine-7 In: Congrès Armand-Frappier 2017 (10e édition), 9-11 novembre 2017, Orford (Québec).

Laplante, Steven . Discovering Drug Seeds by Practical NMR Strategies In: ENC 2016 - 57th Experimental Nuclear Magnetic Resonance Conference, April 9-14, 2016, Pittsburg, United-States of America.

Ayotte, Yann; Descoteaux, Albert et Laplante, Steven . Discovering the seeds for new drugs that target the neglected tropical disease leishmaniasis In: 16e symposium annuel de parasitologie moléculaire du Québec, 6-7 juin 2016, Université McGill, Montréal, QC.

Bernet, Eve; Lebughe, Marthe; Vincent, Antony T.; Haghdoost, Mohammad Mehdi; Golbaghi, Golara; Laplante, Steven; Castonguay, Annie et Veyrier, Frédéric ORCID: https://orcid.org/0000-0002-8574-0547 . Le NaBPh4, une molécule qui tue sélectivement les pathogènes du genre Neisseria In: Journées québécoises de recherche en santé respiratoire 2020 (JQRSR 2020), 9 au 11 novembre 2020, virtuel.