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Multitasking Ru(II) et Ru(III) Complexes Bearing Aromatase Inhibitors with Potential Cytotoxicity and Antimigratory Activities against Breast Cancer Cells

Golbaghi, Golara; Haghdoost, Mohammad Mehdi; Castonguay, Annie . Multitasking Ru(II) et Ru(III) Complexes Bearing Aromatase Inhibitors with Potential Cytotoxicity and Antimigratory Activities against Breast Cancer Cells In: Inorganic Discussion Weekend (IDW), November 3rd-5th 2017, Toronto.

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Résumé

Compared to monotherapy, the administration of a combination of drugs can lead to more efficient and shorter-term treatments with reduced side effects for cancer patients. Of particular interest is the design of anticancer metallic complexes for which all structural components such as the metal, the ligand(s) and/or counterion(s) are carefully selected to accomplish a particular biological function or to result in a molecule with specific intrinsic properties. Many efforts were recently devoted to the design of compounds based on ruthenium complexes to overcome the numerous problems associated with the widely used platinum-based chemotherapeutics. Some ruthenium complexes were found to display fewer side effects than platinum-based drugs, due to their enhanced selectivity, and some were also found to be active against platinum resistant cancer cells, given their various modes of action. We have recently developed a new family of ruthenium (II) and ruthenium (III) complexes that include aromatase enzyme inhibitors in their structure (such as Anastrozole and Letrozole). Aromatase inhibitors are well-known anticancer drugs and are widely used for the treatment of estrogen receptor positive (ER+) breast cancers in postmenopausal women. They inhibit ER+ cancer cell growth by blocking the activity of aromatase, the enzyme responsible for the conversion of androgens to estrogens.In this presentation, we describe the synthetic strategy adopted to afford such multitasking ruthenium complexes, their characterization and the evaluation of their biological activity in relevant cancer cell lines.

Type de document: Document issu d'une conférence ou d'un atelier
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Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 10 sept. 2018 20:41
Dernière modification: 10 sept. 2018 20:41
URI: http://espace.inrs.ca/id/eprint/7513

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