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Ruthenium Complexes as Anticancer Therapeutics

Castonguay, Annie; Haghdoost, Mohammad Mehdi; Golbaghi, Golara; Poulet, Sylvain; Pitard, Irène; Guard, Juliette . Ruthenium Complexes as Anticancer Therapeutics In: 100th Canadian Chemistry Conference and Exhibition 2017 (CSC), May 28-June 1st 2017, Toronto.

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Résumé

Ruthenium-based complexes currently attract great attention as they hold promise to replace platinum-based drugs as first line cancer treatment i)they were found to exhibit considerable activity against cis-platin resistant cell lines. ii) to induce a lower occurence of side effects in comparison to platinum-based therapeutics and iii) to display their antiproliferative activity via different mechanisms. In this presentation, the preparation, caracterization and biological antimigratory activities as well as novel strategies for their thermoresponsive delivery. Moreover, results regarding preliminary in vivo zebrafish embryos toxicity assessment will also be discussed.

Type de document: Document issu d'une conférence ou d'un atelier
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 10 sept. 2018 20:38
Dernière modification: 10 sept. 2018 20:38
URI: http://espace.inrs.ca/id/eprint/7512

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