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IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection.

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Fabié, Aymeric; Mai, Linh Thuy; Hammami, Akil; van Grevenynghe, Julien; Stäger, Simona (2018). IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection. Cell Reports , vol. 24 , nº 5. p. 1163-1175. DOI: 10.1016/j.celrep.2018.06.107.

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Résumé

The transcription factor interferon regulatory factor 5 (IRF-5) plays an important function in innate immunity and in initiating pro-inflammatory responses against pathogens. IRF-5 is constitutively expressed in several cell types, including plasmacytoid dendritic cells, monocytes, and B cells. We have previously reported that IRF-5 is also expressed in T cells during infection. The role of IRF-5 in T cells is yet unknown. Here, we demonstrate that IRF-5 is increasingly expressed in interferon (IFN)-γ+ CD4 T cells over the course of L. donovani infection. This transcription factor is induced by apoptotic material via Toll-like receptor 7 (TLR7) and promotes the expression of death receptor 5 (DR5). IRF-5 activation sensitizes CD4 T cells to cell death. Because tissue disruption and chronic inflammation are common characteristics of persistent infections, activation of IRF-5 in CD4 T cells may represent a common pathway that leads to suppression of protective CD4 T cell responses, favoring the establishment of chronic infection.

Type de document: Article
Mots-clés libres: CD4 T cells; DR5; IRF-5; Leishmania; TLR7; cell death; chronic infection
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 20 févr. 2019 21:49
Dernière modification: 18 mars 2019 18:52
URI: http://espace.inrs.ca/id/eprint/7438

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