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Macrophage Migration Inhibitory Factor (MIF) modulates the activation of T cells during early and late infection with Plasmodium chabaudi adami parasites

Malu, Diane Tshikudi; Bélanger, Benoît; Dardon, Jaime Sanchez; Satoskar, Abhay; Scorza, Tatiana . Macrophage Migration Inhibitory Factor (MIF) modulates the activation of T cells during early and late infection with Plasmodium chabaudi adami parasites In: 9e symposium annuel de parasitologie moléculaire du Québec, 18-19 juin 2009, Université McGill.

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Résumé

Malaria is characterized by potent release of pro-inflammatory cytokines which are involved in pathology and anaemia. Macrophage Migration Inhibitory Factor (MIF) is a pleiotropic cytokine readily released during malaria infection that besides its pro-inflammatory activity has been shown to modulate T cell activation by mitogens and antigens. As MIF neutralization during P.c. adami (DK) infection significantly reduced peak parasitemia and inhibited early IFN-gamma production by splenic T cells and had an opposite stimulatory effect at peak infection, we hypothesized that MIF modulated the early and late T cell response through distinct mechanisms. Our recent data mice confirms an important reduction in peak parasitemia, accompanied by delayed resolution of infection in MIF deficient (MIF KO), which we suggest may correlate with an improved T helper 1 response and delayed B cell activation. IFN-gamma production and TLR2 TLR4 expression by splenic T cells were significantly decreased at day 4 post-infection in MIF KO mice, suggesting early interactions between MIF and T cells.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: Présentation par affiche
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 02 mai 2018 20:59
Dernière modification: 02 mai 2018 21:03
URI: http://espace.inrs.ca/id/eprint/7105

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