Dépôt numérique
RECHERCHER

Occupation, industry, and the risk of prostate cancer: a case-control study in Montreal, Canada

Téléchargements

Téléchargements par mois depuis la dernière année

Plus de statistiques...

Sauvé, Jean-François; Lavoué, Jérome; Parent, Marie-Élise (2016). Occupation, industry, and the risk of prostate cancer: a case-control study in Montreal, Canada Environmental Health , vol. 15 , nº 100. p. 1-19. DOI: 10.1186/s12940-016-0185-1.

[img]
Prévisualisation
Microsoft Excel (données de recherche: Associations between PCa risk (all PCa, low-grade and high-grade PCa) for ever employment and duration of employment, occupations) - Version publiée
Télécharger (458kB) | Prévisualisation
[img] Microsoft Excel (données de recherche: List of occupation and industry categories featuring at least one subject ever employed and <10 subjects ever employed or 0 case or control) - Version publiée
Télécharger (460kB)
[img] Microsoft Excel (données de recherche: Associations between PCa risk (all PCa, low-grade and high-grade PCa) for ever employment and duration of employment, industries) - Version publiée
Télécharger (615kB)
[img]
Prévisualisation
PDF - Version publiée
Disponible sous licence Creative Commons Attribution.

Télécharger (1MB) | Prévisualisation

Résumé

BACKGROUND: Age, family history and ancestry are the only recognized risk factors for prostate cancer (PCa) but a role for environmental factors is suspected. Due to the lack of knowledge on the etiological factors for PCa, studies that are both hypothesis-generating and confirmatory are still needed. This study explores relationships between employment, by occupation and industry, and PCa risk.

METHODS: Cases were 1937 men aged ≤75 years with incident PCa diagnosed across Montreal French hospitals in 2005-2009. Controls were 1994 men recruited concurrently from electoral lists of French-speaking Montreal residents, frequency-matched to cases by age. In-person interviews elicited occupational histories. Unconditional logistic regression estimated odds ratios (OR) and 95 % confidence intervals (CI) for the association between employment across 696 occupations and 613 industries and PCa risk, adjusting for potential confounders. Multinomial logistic models assessed risks by PCa grade. Semi-Bayes (SB) adjustment accounted for the large number of associations evaluated.

RESULTS: Consistently positive associations-and generally robust to SB adjustment-were found for occupations in forestry and logging (OR 1.9, 95 % CI: 1.2-3.0), social sciences (OR 1.6, 95 % CI: 1.1-2.2) and for police officers and detectives (OR: 1.8, 95 % CI 1.1-2.9). Occupations where elevated risk of high grade PCa was found included gasoline station attendants (OR 4.3, 95 % CI 1.8-10.4) and textile processing occupations (OR 1.8, 95 % CI 1.1-3.2). Aside from logging, industries with elevated PCa risk included provincial government and financial institutions. Occupations with reduced risk included farmers (OR 0.6, 95 % CI 0.4-1.0) and aircraft maintenance workers (OR 0.1, 95 % CI 0.0-0.7).

CONCLUSIONS: Excess PCa risks were observed across several occupations, including predominantly white collar workers. Further analyses will focus on specific occupational exposures.

Type de document: Article
Mots-clés libres: Prostate cancer; Occupation; Industry
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 25 mars 2019 16:05
Dernière modification: 25 mars 2019 16:05
URI: http://espace.inrs.ca/id/eprint/6747

Actions (Identification requise)

Modifier la notice Modifier la notice