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Association between metabolic syndrome and gingival inflammation in obese children

Kâ, Khady; Rousseau, Marie-Claude; Tran, Simon D; Henderson, Melanie; Nicolau, Belinda (2018). Association between metabolic syndrome and gingival inflammation in obese children International Journal of Dental Hygiene , vol. 16 , nº 3. p. 397-403. DOI: 10.1111/idh.12322.

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Résumé

BACKGROUND AND OBJECTIVE: Our previous work showed a positive association between metabolic syndrome (MetS) and gingival crevicular fluid (GCF) tumour necrosis factor-alpha (TNF-alpha) in a sample of obese and non-obese children. However, whether this association persists among obese children is unknown. We aim to investigate the extent to which MetS is associated with GCF TNF-alpha level among obese children.

METHODOLOGY: We performed a cross-sectional analysis using data from visit 1 of the Quebec Adipose and Lifestyle InvesTigation in Youth cohort. A total of 219 obese children aged 8-10 years, for whom data were available for both MetS and TNF-alpha, were included in our analysis. The independent variable, MetS, was defined according to the International Diabetes Federation recommendations. GCF samples were collected from the gingival sulcus using a paper strip, and the concentration of TNF-alpha was determined by enzyme-linked immunosorbent assay. Analyses included descriptive statistics and sex-specific linear regression analyses adjusting for potential confounders.

RESULTS: In this sample comprising only obese children, 24 (10.9%) had MetS. Among obese boys, those with MetS had 44.9% higher GCF TNF-alpha (95% confidence interval: 16.5%-73.3%) compared to those without MetS. No such association was detected in obese girls.

CONCLUSION: MetS was positively associated with GCF TNF-alpha concentration in obese boys. These results suggest that obese boys with MetS may have a worse gingival health profile compared to their obese counterpart without MetS.

Type de document: Article
Mots-clés libres: children; metabolic syndrome; tumour necrosis factor‐alpha
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 26 mars 2019 05:22
Dernière modification: 26 mars 2019 05:22
URI: http://espace.inrs.ca/id/eprint/6731

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