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Peripheral oxidative profile and specific advanced glycation end products can be a signature of cognitive decline in Alzheimer's disease

Haddad, Mohamed; Perrotte, Morgane; Le Page, Aurélie; Camponova, Pamela; Fulop, Tamas; Ramassamy, Charles (2017). Peripheral oxidative profile and specific advanced glycation end products can be a signature of cognitive decline in Alzheimer's disease In: OCC World Congress and Annual SFRR-E Conference 2017 Metabolic Stress and Redox Regulation, 21-23 June 2017, Berlin, Germany.

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Résumé

An early diagnosis of Alzheimer's disease (AD) is required for early and more effective treatment. Oxidative stress plays an early role in AD and could promote the formation of advanced glycation end products (AGEs) in AD brains. However, the peripheral association of specific AGEs and oxidative markers with cognitive decline remains to be defined in order to establish a clinical signature for an early diagnosis. Objectives: To measure the total antioxidant capacity (TAC), the levels of protein carbonyl (PC), AGEs precursors (methylglyoxal, MG; glyoxal, GO) and some specific AGEs (pentosidine; carboxylmethyl lysine, CML) and their association with clinical scores (MMSE and MoCA). Methods: These markers were measured in blood from patients with MCI (mild cognitive impairment) and AD at different stages and from age-matched controls by Western blot, ELISA or HPLC. Results: A decrease of TAC and an increase of AGEs precursor's levels (MG and GO) are observed in MCI patients. PC and CML levels raised later in AD groups. Pentosidine levels were not different. Interestingly, PC and CML levels are correlated with cognitive scores. Conclusion: Our results demonstrate that TAC decreases early in MCI stage while some oxidative markers and AGEs precursors increase and are correlated with cognitive decline. Overall, some oxidative stress markers have a potential as biomarkers for AD.

Type de document: Document issu d'une conférence ou d'un atelier
Informations complémentaires: Affiche Scientifique Free Radical Biology and Medicine 108 (sppl 1): http://dx.doi.org/10.1007/s00259-017-3655-y
Mots-clés libres: Blood; Biomarkers; Carboxylmethyl lysine; Protein Carbonyl; Neurodegenerative diseases; Methylglyoxal
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 27 févr. 2019 20:28
Dernière modification: 27 févr. 2019 20:28
URI: http://espace.inrs.ca/id/eprint/6254

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