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Exposure to low environmental concentrations of manganese, lead, and cadmium alters the serotonin system of blue mussels

Fraser, Marc; Fortier, Marlène; Foucher, Delphine; Roumier, Pierre-Herve; Brousseau, Pauline; Fournier, Michel; Surette, Céline; Vaillancourt, Cathy (2017). Exposure to low environmental concentrations of manganese, lead, and cadmium alters the serotonin system of blue mussels Environmental Toxicology and Chemistry , vol. 37 , nº 1. p. 192-200. DOI: 10.1002/etc.3942.

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Résumé

Serotonin plays a crucial role in mussel survival and reproduction. Although serotonin system can be affected by metals, the effects of environmental concentration of metals, such as manganese (Mn), lead (Pd), and cadmium (Cd), have never been studied in blue mussels. This study aims to determine the effects of exposure to Mn, Pb or Cd on serotonin levels, monoamine oxidase (MAO) activity, and serotonin transporter (SERT) in the blue mussel, Mytilus edulis. Mussels were exposed in vivo to increasing and environmentally relevant doses of Mn (10-1000 nM; 0.5-50 microg/L), Pb (0.01-10 nM; 0.002-2 microg/L), or Cd (0.01-10 nM; 0.001-1 microg/L) for 28 days. Serotonin levels, MAO activity, and SERT expression were analyzed in the mussel mantle. SERT protein expression was significantly decreased, by up to 81%, following Mn, Pb, or Cd exposure. MAO activity in females is almost 2-fold higher, versus males, in non- exposed control mussels. In mussels exposed to 0.1 nM of Pb (0.02 microg/L), MAO activity is increased in males, whereas it is decreased in females. In Cd exposed mussels, a sex-dependent, inverted non-monotonic patterns of MAO activity are observed. These results clearly indicate that low environmental concentrations of Mn, Pb, and Cd affect the serotonin system in blue mussels.

Type de document: Article
Mots-clés libres: Heavy metals; Monoamine oxidase; Mytilus edulis; Reproduction; Serotonin transporter
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 27 févr. 2019 20:23
Dernière modification: 27 févr. 2019 20:23
URI: http://espace.inrs.ca/id/eprint/6250

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