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Neighbourhood Walkability and Prostate Cancer Risk: A Population-Based Case-Control Study in Montreal

Demoury, Claire; Cutumisu, Nicoleta; Barnett, Tracie A; Robitaille, Éric; Sigler, Brittany; Richard, Hugues; Rousseau, Marie-Claude; Parent, Marie-Élise . Neighbourhood Walkability and Prostate Cancer Risk: A Population-Based Case-Control Study in Montreal In: Society for Epidemiological Research’s 2016 Epidemiology Congress of the Americas, 21-24 Juin 2016, Miami.

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Résumé

Introduction

Evidence is growing for a beneficial effect of favourable resi- dential characteristics on health. While little evidence on this has accrued re- garding prostate cancer (PCa), engagement in physical activity has been associ- ated with a reduction in risk. We investigated the association between neigh- bourhood walkability and PCa incidence.

Methods

A case - control study was conducted in Greater Montreal. 1,933 incident PCa cases aged ≤75 years were ascertained across French hospitals in 2005 - 2009 and 1,994 age - matched (±5 years) controls were selected from electoral lists. Lifestyle and occupational factors were collected during interviews. Addresses at diagnosis (cases) or recruitment (controls) were geocoded and linked to a neighbourhood walkabil- ity index (dichotomized based on a median split) considering land use mix data, density of dwellings and of intersections of three or more streets in the dissemi- nation area (DA), a census area inhabited by 400 - 700 persons.

Results

Poly- tomous logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between walkability and risk of low and high - grade (Gleason score of 7[4+3] or higher) PCa. Compared to men living in low walkability areas, those in highly walkable areas had an OR of high - grade PCa of 1.23 (95%CI 1.01,1.49), when adjusting for age, ancestry, and first - degree family history. Further adjustments for education, income, marital status, physical activity, body mass index, frequency of physician visits, exposure to traffic - related air pollution, PCa screening frequency, and for mate- rial and social deprivation census - derived indices in the DA, yielded an OR of 1.24 (95%CI 0.96,1.60).

Discussion

Men living in highly walkable areas showed greater risks of high - grade PCa, independently of material and social circumstances, lifestyle and PCa screening practices. Further in - depth analyses will assess the potential for confounding to explain this association.

Type de document: Document issu d'une conférence ou d'un atelier
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Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 25 juin 2018 15:30
Dernière modification: 25 juin 2018 15:30
URI: http://espace.inrs.ca/id/eprint/5764

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