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Ruthenium-based Organometallic Therapeutics and Development of Novel Strategies for their Thermoresponsive Targeted Delivery

Castonguay, Annie; Golbaghi, Golara; Haghdoost, Mohammad Mehdi . Ruthenium-based Organometallic Therapeutics and Development of Novel Strategies for their Thermoresponsive Targeted Delivery In: 99th Canadian Chemistry Conference and Exhibition, 5-9 Juin 2016, Halifax, Nouvelle-Écosse, Canada.

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Résumé

The development of cancer therapies over the past few decades has focused primarily on chemotherapy combined to other treatment approaches such as surgery, radiotherapy, etc. Unfortunately, there are major drawbacks of chemotherapy, i) drugs are not only toxic to cancer cells, but to healthy cells as well, leading numerous undesirable side-effects and ii) the use of a single agent often fails the achieve complete cancer remission, largely due to the development of cancer cell resistance. Compared to purely “organic” compounds, inorganic complexes have unique properties, and can offer great opportunities to the field of chemotherapy, leading the discovery of new models of action for therapeutics, novel interactions with biomolecules, In the presentation, the synthesis and the biological activity assessment of multitasking ruthenium (II) and (III) complexes will be discussed, as well as the development of novel targeted strategies for their delivery via the use of furan-maleimide retro Diels-Alder reactions.

Type de document: Document issu d'une conférence ou d'un atelier
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 30 mars 2018 16:15
Dernière modification: 30 mars 2018 16:16
URI: http://espace.inrs.ca/id/eprint/5744

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