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Effect of Maternal Depression and Prenatal Antidepressant Exposure on Placental Serotoninergic and Glucocorticoids Systems Methylation

Laurent, Laetitia; Penaherrera, Maria; Robinson, Wendy Paige; Oberlander, Tim F.; Vaillancourt, Cathy . Effect of Maternal Depression and Prenatal Antidepressant Exposure on Placental Serotoninergic and Glucocorticoids Systems Methylation In: 57th Annual Meeting- World Spotlight: Elevating Birth Defects Research, 25 Juin 2017, Denver, Colorado.

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Résumé

Up to 20% of women use antidepressant treatment during pregnancy, mainly selective serotonin reuptake inhibitor (SSRI), raising the question about their impact on fetal development and programming. Studies aimed at understanding the effect of SSRIs remain inconsistent and confounded by the concurrent impact of maternal depression. Recently, attention has turned to examining epigenetic mechanisms associated with these two exposures. We hypothesized that these exposures modify the methylation status of genes involved in the serotonin and glucocorticoid systems, both of which are closely related to depression. The methylation status of candidate regions of six genes were analyzed using bisulfite pyrosequencing in the placenta of (N=51) women with or without depression and/or treated with SSRIs. Further, we examined whether fetal sex modified the association between maternal depression and/or SSRIs use during pregnancy and placental methylation. Methylation of the NR3C1 exon 1D region was positively associated with third trimester maternal depression symptoms (ß=0.688; p=0.010), but negatively associated with SSRI exposure (ß=-0.538; p=0.035) in male placentas only. The methylation status of the MAOA first exon-intron was associated with increased maternal depression (ß=0.439; p=0.006), but only in female placentas. Only the MAOA association remained significant after correction for multiple comparisons. The trends observed in our cohort suggest that prenatal maternal depression and SSRI use may modify the methylation status of placental glucocorticoid and serotonin related genes in a sex dependent manner. Larger cohorts are needed to confirm these findings and further our understanding of the potential long-term implications for neonatal and infant health.

Type de document: (NON SPÉCIFIÉ)
Informations complémentaires: DOI: 10.1002/bdr2.106 Birth Defects Research 109:579–618 (2017) p.656.
Mots-clés libres: -
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 05 juill. 2017 20:51
Dernière modification: 05 juill. 2017 20:51
URI: http://espace.inrs.ca/id/eprint/5544

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