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Hypoxia inducible factor 1 alpha: A critical factor for the immune response to pathogens and Leishmania

Charpentier, Tania; Hammami, Akil; Stäger, Simona (2016). Hypoxia inducible factor 1 alpha: A critical factor for the immune response to pathogens and Leishmania Cellular Immunology , vol. 309 . p. 42-49. DOI: 10.1016/j.cellimm.2016.06.002.

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Résumé

Organisms typically react to foreign pathogens by initiating an inflammatory response. However, in order to limit inflammatory tissue injury, it is essential for the organism to maintain the balance between inflammatory and anti-inflammatory responses. Dysregulation of this process can result in the strong inhibition of protective pro-inflammatory responses, and ultimately in pathogen persistence. Chronic infections are often associated with inflammation and tissue disruption. Inflamed tissues are characterized by low levels of oxygen and glucose, a microenvironment that triggers the stabilization of the hypoxia-inducible transcription factor HIF-1 alpha. HIF-1 alpha is the master regulator of the response to hypoxia. Here, we review the role of HIF-1 alpha in the immune response to various pathogens and we highlight how certain microorganisms, including Leishmania parasites, have evolved to hijack the HIF-1 pathway to their advantage.

Type de document: Article
Mots-clés libres: HIF-1α; Immunoregulation; Immunosuppression; Inflammation; Leishmania; Pathogens
Centre: Centre INRS-Institut Armand Frappier
Date de dépôt: 22 févr. 2019 15:51
Dernière modification: 22 févr. 2019 15:51
URI: http://espace.inrs.ca/id/eprint/5482

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